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Difenoxin-Atropine

Pronounced

"dye-fen-OX-in/AT-trow-peen"

Uses

This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It works by slowing the movement of the intestines. Difenoxin is similar to opioid pain relievers, but it acts mainly to slow the gut. Atropine belongs to a class of drugs known as anticholinergics, which help to dry up body fluids and also slow gut movement.

This medication should not be used to treat diarrhea caused by certain types of infection (such as C. difficile-associated diarrhea following antibiotic therapy). Talk to your doctor for more details.

This drug is not recommended for use in children younger than 2 years due to an increased risk of very serious side effects.

How to Use This Medication

Take this medication by mouth as directed by your doctor, usually after each loose stool, or every 3 or 4 hours as needed. The dosage is based on your medical condition and response to treatment. For adults, do not take more than 8 milligrams of difenoxin in any 24-hour period. If you need to continue treatment once your diarrhea is controlled, your doctor may direct you to lower your dosage. Do not increase your dose, take it more often, or use it for longer than prescribed.

It is important that you drink the proper amount of fluids and minerals (electrolytes) to prevent dehydration. Tell your doctor right away if you develop signs of dehydration (such as extreme thirst, decreased urination, muscle cramps, weakness, fainting). You may also need to change to a bland diet during this time to reduce irritation to your stomach/intestines. Consult your doctor or pharmacist for more information.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as stomach cramps, nausea, vomiting). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used this medication for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

Tell your doctor if your condition does not improve after 2 days.

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