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Dornase Alfa

Pronounced

"DOOR-naze AL-fa"

Common brand names:

Pulmozyme

Uses

This medication is used to improve breathing and reduce the risk of lung infections in people with cystic fibrosis. It is used along with other treatments for this disease (such as chest physical therapy, medications, nutritional supplements). Dornase alfa is the same as a substance (DNase I enzyme) that is naturally produced by the body. It works in the airways by decreasing stickiness/thickness of mucus so that it can be cleared from the lungs more easily.

How to Use This Medication

Read the Instructions for Use if available from your pharmacist before you start using dornase alfa and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

This medication is inhaled into the lungs using special breathing equipment as directed by your doctor, usually once or twice daily. A health care professional will show you the proper way to prepare the medication and use the equipment. If you are unclear about any of the instructions, ask your health care professional.

The dosage is based on your medical condition and response to treatment. Do not increase your dose or take this medication more often than prescribed. Your condition will not improve faster and the risk for side effects may be increased.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time(s) each day.

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Drug information is selected from data included with permission and copyrighted by First DataBank, Inc. This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional. Always seek the advice of your healthcare professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your healthcare professional. This information does not contain any assurances that this product is safe, effective or appropriate for you.

This information is intended only for residents of the United States. Products sold under the same brand names in other countries may contain different ingredients.

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Information expires December 2025.