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Insulin Glargine-Lixisenatide

Pronounced

"IN-su-lin GLAR-jeen/LIX-i-SEN-a-tide"

Common brand names:

Soliqua

Uses

This medication is a combination of insulin glargine and lixisenatide and is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

Insulin glargine is a man-made product that is similar to human insulin. It acts longer than regular insulin, providing a low, steady level of insulin. It works by helping blood sugar (glucose) get into cells so your body can use it for energy. Lixisenatide is similar to a natural hormone in your body (incretin). It works by causing insulin release in response to high sugar levels (such as after a meal) and decreasing the amount of sugar your liver makes.

How to Use This Medication

Read the Medication Guide and Instructions for Use provided by your pharmacist before you start using this medication and each time you get a refill. Ask your health care professional how to prepare and use this medication. If you have any questions, ask your doctor or pharmacist.

Inject this medication under the skin as directed by your doctor, usually once daily within 1 hour before the first meal of the day. The injection is given in the thigh, abdomen, or upper arm. Do not inject into a vein or muscle because very low blood sugar (hypoglycemia) may occur. The dosage is based on your medical condition and response to treatment.

Before using, check this product for particles or discoloration. If either is present, do not use the liquid. Before injecting each dose, clean the skin you are going to inject into (the injection site) with rubbing alcohol. Change the injection site each time to lessen injury under the skin (for example, pits/lumps or thickened skin). Do not inject into skin that is red, swollen, itchy, or damaged. To lessen bruising, do not rub the injection site after a shot. Learn how to store and discard medical supplies safely.

Lixisenatide can slow down or decrease the absorption of other drugs such as birth control pills, antibiotics, or acetaminophen. Take other medications at least 1 hour before using this medication. Take birth control pills at least 1 hour before or 11 hours after using this medication. If you must take these other medications with food, take them with a meal or snack when you are not using this product. Ask your doctor or pharmacist if you have any questions about when to take your medications.

Do not share your pen device with another person, even if the needle is changed. You may give other people a serious infection, or get a serious infection from them.

Use this medication regularly to get the most benefit from it. To help you remember, use it with the same meal each day.

Tell your doctor if your condition does not get better or if it gets worse (your blood sugar is too high or too low).

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Drug information is selected from data included with permission and copyrighted by First DataBank, Inc. This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional. Always seek the advice of your healthcare professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your healthcare professional. This information does not contain any assurances that this product is safe, effective or appropriate for you.

This information is intended only for residents of the United States. Products sold under the same brand names in other countries may contain different ingredients.

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Information expires December 2025.