Sofosbuvir-Velpatas-Voxilaprev

Pronounced

"soe-FOS-bue-vir/vel-PAT-as-vir/VOX-i-LA-pre-vir"

Common brand names:

Vosevi

Uses

This medication contains 3 drugs: sofosbuvir, velpatasvir, and voxilaprevir. This medication is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. These drugs work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

It is not known if this treatment can prevent you from passing the virus to others. Do not share needles, and practice "safer sex" (including the use of latex condoms) to lower the risk of passing the virus to others.

How to Use This Medication

Read the Patient Information Leaflet if available from your pharmacist before you start taking sofosbuvir/velpatasvir/voxilaprevir and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with food as directed by your doctor, usually once daily.

This medication works best when the amount of drug in your body is kept at a constant level. Take this drug at evenly spaced times. To help you remember, take it at the same time each day.

Continue to take this medication for the full length of time prescribed, even if symptoms disappear after a short time. Stopping the medication too early may result in a return of the infection.

Antacids lower the absorption of velpatasvir. If you are taking an antacid, take it at least 4 hours before or 4 hours after this medication.

Other acid-lowering medications for indigestion, heartburn, or ulcers (such as prescription or over-the-counter medications including famotidine, omeprazole) may prevent velpatasvir from working. Ask your doctor or pharmacist how to use these medications safely.

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Information expires December 2025.