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Trastuzumab-Hyaluronidase-Oysk

Pronounced

"tras-TOOZ-ue-mab"

Common brand names:

Herceptin SC

Uses

Trastuzumab is used to treat a certain type of breast cancer that makes more than usual amounts of a substance in your body (HER2 protein). Trastuzumab belongs to a class of medications known as monoclonal antibodies. It works by slowing or stopping the growth of cancer cells. This product also contains hyaluronidase, which helps your body absorb trastuzumab given by injection under the skin.

This monograph is about the following trastuzumab products: trastuzumab (subcutaneous) and trastuzumab-hyaluronidase-oysk. These products are not the same as other trastuzumab products, including trastuzumab emtansine, or trastuzumab given by injection into a vein, and should not be used in place of each other.

How to Use This Medication

This medication is given by slow injection under the skin by a health care professional, over 2 to 5 minutes, usually once every 3 weeks. It is given in the thigh, and the injection site and side are changed each time to lessen injury under the skin.

The dosage is based on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, mark the days on the calendar when you need to receive the medication.

Serious reactions, including an allergic reaction, may happen with your injection, usually within 24 hours after your dose. Careful monitoring may decrease your risk. Get medical help right away if you have symptoms such as fever, chills, flushing, headache, nausea/vomiting, coughing, chest pain, trouble breathing, itching/swelling (especially of the face/tongue/throat), dizziness, weakness, or feeling faint.

Your doctor may prescribe other medications (such as acetaminophen, diphenhydramine) for you to take before each dose to help prevent serious side effects. Follow your doctor's directions carefully.

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Drug information is selected from data included with permission and copyrighted by First DataBank, Inc. This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional. Always seek the advice of your healthcare professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your healthcare professional. This information does not contain any assurances that this product is safe, effective or appropriate for you.

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Information expires December 2025.