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Trifluridine-Tipiracil

Pronounced

"trye-FLURE-i-deen/tye-PIR-a-sil"

Common brand names:

Lonsurf

Uses

This medication is used to treat certain cancers (such as stomach, colon/rectum). It works by slowing or stopping the growth of cancer cells.

How to Use This Medication

Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

This drug is not taken every day. On the days you are supposed to take this medication, take it by mouth as directed by your doctor, usually twice in one day. Take your dose within 1 hour after eating your morning and evening meals. Swallow the tablets whole. Do not crush or chew. Follow your doctor's directions exactly.

The dosage is based on your body size, medical condition, and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times on the days your doctor directs.

If you vomit after taking a dose, do not take another dose at that time. Take your next dose at the regular time.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets. You and your caregiver should wear gloves when handling this medication. Wash your hands after handling the tablets.

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Drug information is selected from data included with permission and copyrighted by First DataBank, Inc. This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional. Always seek the advice of your healthcare professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your healthcare professional. This information does not contain any assurances that this product is safe, effective or appropriate for you.

This information is intended only for residents of the United States. Products sold under the same brand names in other countries may contain different ingredients.

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Information expires December 2025.