Schizophrenia
| Supplement | Amount | Why |
|---|---|---|
Glycine | 0.8 grams for every 2.2 lbs (1 kg) of body weight under medical supervision |  [3 stars] Supplementing with glycine appears to help improve depression and mental symptoms and may reduce symptoms in people unresponsive to drug therapy. |
Fish Oil | 2,000 to 3,000 mg daily of EPA |  [2 stars] Omega-6 and omega-3 fatty acids appear to be deficient or improperly used in people with schizophrenia. Supplementing with fish oil may correct an imbalance and improve symptoms. |
L-Tryptophan | 1 to 8 grams per day (under a doctor's supervision) | [2 stars] L-tryptophan supplementation has occasionally been helpful for specific schizophrenia symptoms, such as aggression and memory function.
|
Vitamin B3 (Niacin) | Consult a qualified healthcare practitioner | [2 stars] High amounts of vitamin B3 may create a more optimal biochemical environment and increase recovery rate and reduce hospitalization and suicide rates. |
Vitamin B6 | Consult a qualified healthcare practitioner | [2 stars] Vitamin B6 has been used in combination with niacin in the treatment of schizophrenia with some reported benefits. |
Vitamin B6, Vitamin B12, and Folic Acid (High Homocysteine) | Take folic acid (2 mg), vitamin B6 (25 mg), and vitamin B12 (400 mcg) daily | [2 stars] People with schizophrenia who have high homocysteine levels may improve symptoms by supplementing with folic acid, vitamin B6, and vitamin B12. |
Vitamin C | Consult a qualified healthcare practitioner | [2 stars] People with schizophrenia may require more vitamin C than the general population. In one trial, vitamin C reduced hallucinations, suspiciousness, and disorganized thoughts. |
D-Serine | Refer to label instructions |  [1 star] Supplementing with the amino acid D-serine may improve mental symptoms in people with schizophrenia who are also taking antipsychotic medications. |
Vitamin B12 | Refer to label instructions | [1 star] People with schizophrenia may have low vitamin B12 levels. Supplementing with the vitamin may correct an imbalance and improve symptoms. |
- Reliable and relatively consistent scientific data showing a substantial health benefit.
- Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
- For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by some in the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.