Supplement | Amount | Why |
---|---|---|
Alpha-Lipoic Acid | 600 to 1,200 mg daily | [3 stars] Taking alpha lipoic acid may improve insulin sensitivity and help protect against diabetic complications such as nerve damage. |
Brewer’s Yeast | 9 grams (about 2 teaspoons) daily | [3 stars] Chromium-rich brewer’s yeast has been shown to be useful in treating type 2 diabetes in several ways, including by improving blood glucose control. |
Cayenne Topical (Diabetic Neuropathy) | Apply an ointment containing 0.025 to 0.075% capsaicin four times daily to areas of nerve pain | [3 stars] Topically applied capsaicin (from cayenne) may help relieve nerve pain. |
Chromium | 200 to 500 mcg daily, or more under doctor supervision | [3 stars] Chromium has been shown to be useful in treating type 2 diabetes in several ways, including by improving blood glucose control. |
Fenugreek | 5 grams or more daily | [3 stars] Fenugreek seeds appears to lower blood glucose levels by slowing down carbohydrate digestion and absorption. |
Fiber | 15 grams (about 1 tablespoon) daily | [3 stars] Taking fiber supplements may improve blood glucose control and reduce insulin resistance in people with type 2 diabetes. |
Folic Acid | 6 mg methylfolate daily | [3 stars] Folic acid supplementation may improve blood glucose control and insulin sensitivity in people with type 2 diabetes. Folic acid also lowers homocysteine levels and preliminary evidence suggests it may help to prevent and treat diabetes complications. |
Glucomannan | 1 to 10 grams daily | [3 stars] Glucomannan delays stomach emptying, leading to more gradual glucose absorption and lower blood glucose levels after meals. |
Magnesium | 200 to 600 mg of elemental magnesium daily | [3 stars] People with type 2 diabetes tend to have low magnesium levels. Supplementing with magnesium may improve glucose metabolism and help prevent diabetes-related cardiovascular disease. |
Probiotics | 7 billion CFU or more of a mix of probiotic strains daily | [3 stars] Probiotics can improve blood glucose control, as well as cholesterol and triglyceride levels, in people with type 2 diabetes. |
Psyllium | 5 grams (about 1 teaspoon) twice daily with meals | [3 stars] Supplementing with psyllium has been shown to be a safe and well-tolerated way for people with type 2 diabetes to improve control of blood glucose and cholesterol levels. |
Acetyl-L-Carnitine (Diabetic Neuropathy) | 500 to 1,000 mg three times daily | [2 stars] Taking acetyl-L-carnitine may improve symptoms of diabetic neuropathy. |
Aloe | 100 to 300 mg daily | [2 stars] Aloe vera leaf gel may help lower blood glucose levels and hemoglobin-A1c, a marker of long-term glycemic control, in people with type 2 diabetes. |
American Ginseng | 1 gram three times daily | [2 stars] Supplementing with American ginseng may help improve blood glucose control and insulin sensitivity in people with type 2 diabetes. |
Asian Ginseng | 5 grams of powdered root or an equivalent dose of Asian ginseng extract daily | [2 stars] Asian ginseng may help restore healthy insulin sensitivity and improve blood glucose and lipid levels in people with type 2 diabetes. |
Berberine (High Cholesterol) | 500 mg two to three times daily | [2 stars] Berberine may improve blood glucose control and insulin sensitivity and decrease risks of cardiovascular and other complications in people with type 2 diabetes. |
Bilberry | 160 mg two to three times daily | [2 stars] Bilberry may improve glucose metabolism and lower the risk of some diabetic complications, such as diabetic retinopathy. |
Biotin | 9 to 15 mg daily | [2 stars] Biotin may improve glucose and triglyceride levels in people with type 2 diabetes and reduce pain from diabetic nerve damage. |
Bitter Melon | 2 grams daily | [2 stars] Bitter melon may help lower blood glucose levels and improve overall metabolism in people with type 2 diabetes. |
Cinnamon | 1 to 3 grams daily | [2 stars] Cinnamon may improve glucose levels in people with type 2 diabetes. |
Coenzyme Q10 | 100 to 200 mg daily | [2 stars] Supplementing with CoQ10 may improve blood glucose control, insulin sensitivity, and cardiovascular health. |
Crepe Myrtle | 32 or 48 mg of an herbal extract standardized to contain 1% corosolic acid | [2 stars] Crepe myrtle has been used in folk medicine to treat diabetes, and preliminary research suggests it may lower blood glucose levels. |
Green Tea | The best effective dose is unknown, but doses providing 450 mg of total green tea polyphenols (catechins) daily are considered moderate; doses providing 800 mg of EGCG or more daily have been linked to liver injury and are not considered safe. | [2 stars] Green tea may protect cardiovascular health and improve metabolism. |
Gymnema | 400 to 1,000 mg daily | [2 stars] Gymnema may stimulate the pancreas to produce insulin and help normalize blood glucose control in people with type 2 diabetes. |
Hairy Basil | 10 grams three times daily with meals | [2 stars] Taking hairy basil seeds may help lower blood glucose levels in people with type 2 diabetes. |
Holy Basil | 1,000 to 2,500 mg daily | [2 stars] Taking holy basil may help people with type 2 diabetes control their blood glucose levels. |
L-Carnitine | 2 to 4 grams daily | [2 stars] Supplementing with L-carnitine may reduce glucose, cholesterol, and triglyceride levels, and support medical therapies for type 2 diabetes. |
Milk Thistle | 140 mg of silymarin three times daily | [2 stars] Supplementing with milk thistle extract may improve blood glucose levels, HbA1c, and insulin sensitivity, and reduce oxidative stress and inflammation. |
Multivitamin (Infection) | Follow label instructions | [2 stars] Supplementing with a multivitamin–mineral may give your body the nutrients it needs to help prevent common infections. |
Onion | 2 to 3.5 ounces fresh onion daily | [2 stars] Onion may lower blood glucose levels and improve glucose tolerance in people with type 2 diabetes. |
Pine Bark Extract (Pycnogenol) | 100 to 200 mg daily | [2 stars] Pycnogenol may improve blood glucose control and help prevent diabetes complications such as retinopathy in people with type 2 diabetes. |
Pinitol | 400 mg three times daily | [2 stars] Pinitol may improve glucose metabolism in people with type 2 diabetes. |
Vitamin B1 and Vitamin B12 (Diabetic Neuropathy) | Refer to label instructions | [2 stars] Taking vitamin B1 combined with vitamin B12 may improve symptoms of diabetic neuropathy. |
Vitamin B1 and Vitamin B6 (Diabetic Neuropathy) | 25 mg of vitamin B1 daily, with 50 mg of vitamin B6 daily | [2 stars] Taking vitamin B1 combined with vitamin B6 may improve symptoms of diabetic neuropathy. |
Vitamin B12 (Diabetic Neuropathy) | 1 to 10 mg daily | [2 stars] Vitamin B12 deficiency is common in people being treated medically for type 2 diabetes. Supplementation can restore healthy levels and prevent dangerous long-term consequences of B12 deficiency. |
Vitamin B6 | 35 mg of pyridoxal 5-phosphate twice daily | [2 stars] People with type 2 diabetes, and especially those with diabetes complication, tend to have low levels of active vitamin B6, a nutrient needed for healthy metabolism. |
Vitamin C | 500 mg one to two times daily | [2 stars] Supplementing with vitamin C may lower blood glucose levels and protect cardiovascular health. |
Vitamin D (Diabetic Neuropathy) | 2,000 IU of vitamin D daily for three months | [2 stars] In a preliminary trial, supplementing with vitamin D per day significantly improved pain by almost 50% in patients with diabetic neuropathy. |
Vitamin D | 1,332 IU daily | [2 stars] 4,000 IU per day |
Vitamin E (Diabetic Retinopathy) | 1800 IU daily | [2 stars] Vitamin E supplementation may protect against diabetic retinopathy. |
Vitamin E (Diabetic Neuropathy) | 900 IU daily | [2 stars] Vitamin E supplementation may protect against neuropathy. |
Zinc | 15 to 25 mg of elemental zinc daily | [2 stars] People with type 2 diabetes, especially those being treated with anti-diabetes medications, tend to be zinc deficient. In those with zinc deficiency, supplementation may improve blood glucose regulation and reduce insulin resistance. |
Açaí | 100 grams (about 3 ounces) açai berry pulp or the equivalent daily | [1 star] Preliminary evidence suggests açai may have benefits in type 2 diabetes. |
Amylase Inhibitors | Varies depending on source | [1 star] Amylase inhibitors from various medicinal herbs and plant foods may reduce the usual after-meal rise in blood glucose levels in people with diabetes. |
Coffee | Amount providing 400 to 450 mg chlorogenic acid daily | [1 star] Drinking either regular or decaffeinated coffee has been associated with reduced type 2 diabetes risk in several studies. |
Evening Primrose Oil | 4 grams daily | [1 star] Preliminary research suggests evening primrose oil may be helpful for preventing and treating diabetic neuropathy. |
Fish Oil | 6 grams (about 1.25 teaspoons) of fish oil, providing approximately 2,000 mg of combined EPA and DHA, daily | [1 star] Supplementing with fish oil can reduce inflammation and may lower triglyceride and cholesterol levels in people with type 2 diabetes. |
Fructo-oligosaccharides | 10 to 20 grams (about 2 to 4 teaspoons) daily | [1 star] Fructo-oligosaccharides improve metabolic healthy by supporting growth of beneficial bacteria in the gut. Supplementing with fructo-oligosaccharides may improve blood glucose and lipid levels. |
Ginkgo | 120 mg daily | [1 star] Ginkgo may improve the efficacy of commonly used anti-diabetes medications. It also appears to help prevent and treat type 2 diabetes-related complications. |
Goldenseal | 1 gram daily of berberine for two months | [1 star] Preliminary research with berberine (an active compound in goldenseal) for two months lowered blood glucose levels in people with type 2 diabetes.
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Hibiscus | One cup of hibiscus tea two to three times daily | [1 star] Hibiscus is a traditional remedy for diabetes. Preliminary research suggests it may lower blood pressure and improve lipid levels in people with type 2 diabetes. |
Inositol | 500 to 2,000 mg daily | [1 star] Inositol has been shown to improve glucose metabolism and insulin sensitivity in women with polycystic ovarian syndrome, and preliminary evidence suggests it may lower HbA1c in people with type 2 diabetes. |
Manganese | 1.8 to 2.6 mg daily | [1 star] Manganese is important as an antioxidant and metabolic regulator. Supplementation to prevent deficiency may be helpful for people with type 2 diabetes. |
Medium-Chain Triglycerides | 1 to 3 tablespoons MCT oil daily | [1 star] Replacing other dietary fats with medium-chain triglycerides may lead to metabolic benefits in people with type 2 diabetes. |
Mistletoe | Refer to label instructions | [1 star] Mistletoe extract has been shown to stimulate insulin release from pancreas cells, and it may reduce diabetes symptoms. |
Moringa | Refer to label instructions | [1 star] Moringa has been used traditionally to treat diabetes. |
Olive Leaf | 500 mg of olive leaf extract or three cups of olive leaf tea daily | [1 star] Preliminary research suggests olive leaf may improve glucose metabolism and have benefits for people with type 2 diabetes. |
Quercetin | Refer to label instructions | [1 star] Quercetin has been found to improve glucose metabolism and reduce complications in animal models of type 2 diabetes. |
Reishi | Refer to label instructions | [1 star] Reishi may have some beneficial action in people with diabetes. |
Taurine | Refer to label instructions | [1 star] Supplementing with taurine may affect insulin secretion and action and may help some people with type 2 diabetes. |
Vanadium | Refer to label instructions | [1 star] Vanadyl sulfate, a form of vanadium, may improve glucose control in people with type 2 diabetes. |
Vitamin B3 (Niacin) | Less than 2 grams daily | [1 star] Dietary niacin (vitamin B3) is important for healthy management of cholesterol and triglycerides; however, high dose supplementation with niacin could worsen glycemic control in people with type 2 diabetes. |
Yerba Mate | Refer to label instructions | [1 star] Preliminary research suggests yerba mate (Ilex paraguariensis) tea may improve measures of blood glucose control in people with type 2 diabetes. |
Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by some in the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.