5-HTP
5-hydroxytryptophan is used by the human body to make serotonin, an important substance for normal nerve and brain function. Serotonin appears to play significant roles in sleep, emotional moods, pain control, inflammation, intestinal peristalsis, and other body functions.1
- Reliable and relatively consistent scientific data showing a substantial health benefit.
- Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
- For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
This supplement has been used in connection with the following health conditions:
| Used for | Amount | Why |
|---|---|---|
Depression | Consult a qualified healthcare practitioner |  [2 stars] Depression has been linked to serotonin imbalances in the brain. Supplementing with 5-HTP may increase serotonin synthesis and reduce symptoms. |
Fibromyalgia | 100 mg three times per day | [2 stars] Supplementing with 5-HTP may ease symptoms. |
Insomnia | Adults: 200 mg two hours before bedtime and 400 mg at bedtime; children: 3 mg per 2.2 lbs (1 kg) body weight | [2 stars] 5-HTP is converted into serotonin and might, therefore, be helpful for insomnia. In one study, supplementing with 5-HTP appeared to improve sleep quality. |
Migraine Headache | 200 to 600 mg daily for adults, 20 mg for every 10 pounds of body weight for children | [2 stars] Several studies have found 5-HTP to be effective at reducing the frequency, severity, and duration of migraine headaches. |
Obesity | Take under medical supervision: 600 to 900 mg daily for no more than 12 weeks | [2 stars] 5-HTP has been shown to reduce appetite and to promote weight loss. |
Sleep Disturbances | Refer to label instructions | [2 stars] 5-HTP is used by the human body to make serotonin, an important substance for normal nerve and brain function. Serotonin appears to play significant roles in sleep. |
Tension Headache | Adults: 300 mg daily; children: 100 mg daily | [2 stars] Taking the supplement 5-hydroxytryptophan may lessen headache frequency and limit the need for pain-relieving medications. |
Bipolar Disorder | Refer to label instructions |  [1 star] Supplementing with 5-HTP has had antidepressant effects in people with bipolar disorder; the effect was greater when combined with an antidepressant drug (doctor's supervision recommended)
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Eating Disorders | Refer to label instructions | [1 star] 5-HTP has been shown to reduce appetite in weight-control and diabetes trials. However, what effect 5-HTP has on people with eating disorders is unknown |
Seasonal Affective Disorder | 900 mg a day of a standardized extract | [1 star] The supplement 5-Hydroxytryptophan increases serotonin production and has shown antidepressant activity. It may be useful in the treatment of SAD. |
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.