No serious side effects have been reported with 300–400 mg per day. Larger amounts (such as 8 grams per day or more) may cause low blood sugar, rash, fever, and (on rare occasions) liver damage.1 One report exists of vitiligo appearing after ingestion of large amounts of PABA2 and use of amounts over 20 grams per day in small children has resulted in deaths.3 There is also a report of a death from toxic hepatitis in a person with lupus, who took as much as 48 grams per day for six days, followed by 8 grams per day for seven months.4
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.