Pau D’arco
© Steven FosterSide Effects
High amounts (several grams daily over several days) of lapachol can cause uncontrolled bleeding, nausea, and vomiting.7 Use of the whole bark is typically safer than isolated lapachol—side effects have included nausea and gastrointestinal upset.8Pregnant or breast-feeding women should avoid use of pau d’arco.
One case report exists of a 28-year-old man who died of liver failure after taking unspecified amounts of pau d’arco, scullcap, and zinc.9 It appears likely that this may have been a case of adulteration of scullcap with germander.10
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.