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Drug

Promethazine

Common brand names:

Phenadoz, Phenergan, Promethegan

Promethazine is an antihistamine used to relieve allergic rhinitis (seasonal allergy) symptoms including sneezing, runny nose, itching, and watery eyes and itching and swelling associated with uncomplicated allergic skin reactions. It is also used as a sleep aid for surgical procedures and to prevent/treat motion sickness, nausea, and vomiting. Promethazine is available as a nonprescription product alone and in a combination product to treat symptoms of allergy, colds, and upper respiratory infections. It is also available in prescription products with codeine, to treat coughs associated with colds and upper respiratory infections.

Summary of Interactions with Vitamins, Herbs, & Foods

Negative Interactions
1
- Promethazine
  Henbane
  Potential Negative Interaction
  Antihistamines, including promethazine, can cause “anticholinergic” side effects such as dryness of mouth and heart palpitations. Henbane also has anticholinergic activity and side effects. Therefore, use with promethazine could increase the risk of anticholinergic side effects, though apparently no interactions have yet been reported with promethazine and henbane. Henbane should not be taken except by prescription from a physician trained in its use, as it is extremely toxic.
  Henbane
  Promethazine
  ×
  1. Blumenthal M, ed. The Complete German Commission E Monographs. Austin, TX: American Botanical Council, 1998, 146.

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.