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Drug

Allopurinol

Common brand names:

Zyloprim

Pronounced

"AL-oh-PURE-i-nol"

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (such as prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug are: "blood thinners" (such as warfarin), capecitabine, didanosine, fezolinetant.

Supportive Interactions
1
- Allopurinol
  L-Tryptophan
  Support Medicine
  In a preliminary study, seven of eight individuals with severe mental depression showed improvement when they took L-tryptophan and allopurinol; of these seven, five experienced full remission. Controlled research is necessary to determine whether this combination might be more effective for severe depression than standard treatment.
  L-Tryptophan
  Allopurinol
  ×
  1. Stern SL, Mendels J. Drug combinations in the treatment of refractory depression: a review. J Clin Psychiatry 1981;42:368-73.
Explanation Required
2
- Allopurinol
  L-Carnitine
  Needs Explanation
  People who have Duchenne muscular dystrophy have low levels of L-carnitine in their muscles. Allopurinol restores L-carnitine to normal levels, resulting in improved muscle strength. Whether L-carnitine supplementation might improve this effect of allopurinol has not been investigated.
  L-Carnitine
  Allopurinol
  ×
  1. Camina F, Novo-Rodriguez MI, Rodriguez-Segade S, Castro-Gago M. Purine and carnitine metabolism in muscle of patients with Duchenne muscular dystrophy. Clin Chim Acta 1995;243:151-64.
- Allopurinol
  Vitamin D
  Needs Explanation
  Individuals with gout have low blood concentration of the active form of vitamin D (1,25 dihydroxycholecalciferol), and allopurinol corrects this problem.
  Vitamin D
  Allopurinol
  ×
  1. Takahashi S, Yamamoto T, Moriwaki Y, et al. Decreased serum concentrations of 1, 25 (OH)2-vitamin D3 in patients with gout. Metabolism 1998;47:336-8.