Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Amantadine may interfere with the effect of certain vaccines, such as flu vaccine inhaled through the nose. However, you may get a flu shot (flu vaccine given by injection) if recommended by your doctor.