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Drug

Amiodarone

Common brand names:

Cordarone

Pronounced

"A-mi-OH-da-rone"

Drug Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: fingolimod, certain drugs to treat hepatitis C (ledipasvir/sofosbuvir, sofosbuvir).

Many drugs besides amiodarone may affect the heart rhythm (QT prolongation), including dofetilide, levoketoconazole, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as clarithromycin, erythromycin), quinolone antibiotics (such as levofloxacin), among others.

Other medications can affect the removal of amiodarone from your body, which may affect how amiodarone works. Examples include azole antifungals (such as itraconazole), cimetidine, cobicistat, protease inhibitors (such as fosamprenavir), rifamycins (such as rifampin), St. John's wort, among others.

Amiodarone can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include clopidogrel, macitentan, phenytoin, certain "statin" drugs (atorvastatin, lovastatin), trazodone, warfarin, among others.

Negative Interactions
2
- Amiodarone
  Grapefruit
  Potential Negative Interaction
  In one controlled study, drinking grapefruit juice while taking amiodarone dramatically increased blood levels of the drug. Consequently, people taking amiodarone should avoid drinking grapefruit juice (and eating grapefruit) to prevent potentially serious side effects.
  Grapefruit
  Amiodarone
  ×
  1. Libersa CC, Brique SA, Motte KB, et al. Dramatic inhibition of amiodarone metabolism induced by grapefruit juice. Br J Clin Pharmacol 2000;49:373-8.
- Amiodarone
  Pomegranate
  Potential Negative Interaction
  Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice. The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with amiodarone in the same way that grapefruit juice does.
  Pomegranate
  Amiodarone
  ×
  1. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6.
  2. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472-3.
Supportive Interactions
1
- Amiodarone
  Vitamin E
  Reduce Side Effects
  Test tube research on human lung tissue suggests that vitamin E might reduce lung toxicity caused by amiodarone. More research is needed to further investigate this possibility.
  Vitamin E
  Amiodarone
  ×
  1. Kachel DL, Moyer TP, Martin WJ 2d. Amiodarone-induced injury of human pulmonary artery endothelial cells: Protection by alpha-tocopherol. J Pharmacol Exp Ther 1990;254:1107-12.