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Drug

Bismuth Subsalicylate

Common brand names:

Pepto-Bismol

Pronounced

"BIZ-muth sub-sal-ISS-ill-ate"

Drug Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug are: valproic acid, carbonic anhydrase inhibitors (such as acetazolamide), corticosteroids (such as prednisone), dichlorphenamide, methotrexate.

This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.

Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, or naproxen) that are similar to this drug and, if taken together, may increase your risk for side effects. However, if your doctor has told you to take low-dose aspirin to prevent heart attack or stroke (usually 81-162 milligrams a day), you should keep taking the aspirin unless your doctor tells you not to. Ask your doctor or pharmacist for more details.

This medication may interfere with certain medical/lab tests (such as x-rays of the intestines using contrast dye), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Negative Interactions
4
- Bismuth Subsalicylate
  Meadowsweet
  Potential Negative Interaction
  Bismuth subsalicylate contains salicylates. Various herbs including meadowsweet (Filipendula ulmaria), poplar (Populus tremuloides),willow (Salix alba), and wintergreen (Gaultheria procumbens) contain salicylates as well. Though similar to aspirin, plant salicylates have been shown to have different actions in test tube studies. Furthermore, salicylates are poorly absorbed and likely do not build up to levels sufficient to cause negative interactions that aspirin might. No reports have been published of negative interactions between salicylate-containing plants and aspirin or aspirin-containing drugs. Therefore concerns about combining salicylate-containing herbs remain theoretical, and the risk of causing problems appears to be low.
  Meadowsweet
  Bismuth Subsalicylate
  ×
  1. Wichtl M, Bisset NG, eds. Herbal Drugs and Phytopharmaceuticals Stuttgart: Medpharm GmBH Scientific Publishers. 1994.
  2. Janssen PL, Katan MB, van Staveren WA, et al. Acetylsalicylate and salicylates in foods. Cancer Lett 1997:114(1-2):163-4.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Product Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 154-5.
- Bismuth Subsalicylate
  Poplar
  Potential Negative Interaction
  Bismuth subsalicylate contains salicylates. Various herbs including meadowsweet (Filipendula ulmaria), poplar (Populus tremuloides),willow (Salix alba), and wintergreen (Gaultheria procumbens) contain salicylates as well. Though similar to aspirin, plant salicylates have been shown to have different actions in test tube studies. Furthermore, salicylates are poorly absorbed and likely do not build up to levels sufficient to cause negative interactions that aspirin might. No reports have been published of negative interactions between salicylate-containing plants and aspirin or aspirin-containing drugs. Therefore concerns about combining salicylate-containing herbs remain theoretical, and the risk of causing problems appears to be low.
  Poplar
  Bismuth Subsalicylate
  ×
  1. Wichtl M, Bisset NG, eds. Herbal Drugs and Phytopharmaceuticals Stuttgart: Medpharm GmBH Scientific Publishers. 1994.
  2. Janssen PL, Katan MB, van Staveren WA, et al. Acetylsalicylate and salicylates in foods. Cancer Lett 1997:114(1-2):163-4.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Product Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 154-5.
- Bismuth Subsalicylate
  White Willow
  Potential Negative Interaction
  Bismuth subsalicylate contains salicylates. Various herbs including meadowsweet (Filipendula ulmaria), poplar (Populus tremuloides),willow (Salix alba), and wintergreen (Gaultheria procumbens) contain salicylates as well. Though similar to aspirin, plant salicylates have been shown to have different actions in test tube studies. Furthermore, salicylates are poorly absorbed and likely do not build up to levels sufficient to cause negative interactions that aspirin might. No reports have been published of negative interactions between salicylate-containing plants and aspirin or aspirin-containing drugs. Therefore concerns about combining salicylate-containing herbs remain theoretical, and the risk of causing problems appears to be low.
  White Willow
  Bismuth Subsalicylate
  ×
  1. Wichtl M, Bisset NG, eds. Herbal Drugs and Phytopharmaceuticals Stuttgart: Medpharm GmBH Scientific Publishers. 1994.
  2. Janssen PL, Katan MB, van Staveren WA, et al. Acetylsalicylate and salicylates in foods. Cancer Lett 1997:114(1-2):163-4.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Product Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 154-5.
- Bismuth Subsalicylate
  Wintergreen
  Potential Negative Interaction
  Bismuth subsalicylate contains salicylates. Various herbs including meadowsweet (Filipendula ulmaria), poplar (Populus tremuloides),willow (Salix alba), and wintergreen (Gaultheria procumbens) contain salicylates as well. Though similar to aspirin, plant salicylates have been shown to have different actions in test tube studies. Furthermore, salicylates are poorly absorbed and likely do not build up to levels sufficient to cause negative interactions that aspirin might. No reports have been published of negative interactions between salicylate-containing plants and aspirin or aspirin-containing drugs. Therefore concerns about combining salicylate-containing herbs remain theoretical, and the risk of causing problems appears to be low.
  Wintergreen
  Bismuth Subsalicylate
  ×
  1. Wichtl M, Bisset NG, eds. Herbal Drugs and Phytopharmaceuticals Stuttgart: Medpharm GmBH Scientific Publishers. 1994.
  2. Janssen PL, Katan MB, van Staveren WA, et al. Acetylsalicylate and salicylates in foods. Cancer Lett 1997:114(1-2):163-4.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Product Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 154-5.