Drug
Buprenorphine
Pronounced
"BUE-pre-NOR-feen"
Uses
Buprenorphine is used to treat opioid use disorder. This long-acting form of buprenorphine should be used after starting treatment with a single dose of a transmucosal form of buprenorphine (one that is used under the tongue or inside the cheek) or after being treated with buprenorphine. Buprenorphine belongs to a class of drugs known as mixed opioid agonist-antagonists. It helps prevent withdrawal symptoms caused by stopping other opioids. It is used as part of a complete treatment program for opioid use disorder (such as compliance monitoring, counseling, behavioral contract, lifestyle changes).
Warning
This medication must be given only by injection under the skin. This form of buprenorphine changes from a liquid to a more solid form upon contact with body fluids, so giving it by injection into a vein or muscle may cause serious harm or death. Blockage, dangerous blood clots, or local injury can happen if this medication is not used properly.
Ask your doctor or pharmacist if you should have naloxone available to treat opioid overdose. Teach your family or household members about the signs of an opioid overdose and how to treat it.
How to Use This Medication
Read the Medication Guide provided by your pharmacist before you start using buprenorphine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
This medication is given by injection under the skin by a health care professional, as directed by your doctor. Depending on your brand, it will be given either once monthly after the first 2 injections, or once weekly. After the injection, this medication changes from a liquid to a more solid form (depot). You may see or feel a small bump under your skin at the injection site. The bump will get smaller over time. Do not try to remove the depot. Do not rub or massage the injection site. Try not to let belts or clothing waistbands rub against the injection site.
The dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, mark your calendar with a reminder. If you miss a dose, contact your doctor or pharmacist right away.
If you suddenly stop using this medication, you may have withdrawal symptoms (such as restlessness, watering eyes, runny nose, nausea, sweating, muscle aches). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used buprenorphine for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.