This combination medication is used by women with a uterus to reduce symptoms of menopause (such as hot flashes, vaginal dryness) and to prevent bone loss (osteoporosis) after menopause. It contains conjugated estrogens and bazedoxifene. Conjugated estrogens are hormones which help decrease menopausal symptoms caused by the body making less estrogen. Bazedoxifene is not an estrogen hormone, but it acts like estrogen in some parts of the body, such as the bones. Bazedoxifene slows down bone loss and helps keep bones strong, making them less likely to break. In other parts of the body, such as the uterus, bazedoxifene acts like an estrogen blocker and reduces the risk of cancer of the uterus that can be caused by using estrogen. Bazedoxifene belongs to a class of drugs known as selective estrogen receptor modulators-SERMs.

If you are using this medication to treat symptoms only in and around the vagina, consider using products applied directly inside the vagina instead of medications that are taken by mouth, absorbed through the skin, or injected.