Aisle7 Demo Web

Drug

Est Estrogens-Methyltest

Pronounced

"METH-ill-tess-TOSS-ter-own/ESS-trow-jen"

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: anastrozole, "blood thinner" (warfarin), corticosteroids (such as prednisone), exemestane, fezolinetant, ospemifene, raloxifene, tamoxifen, tranexamic acid.

Other medications can affect the removal of estrogens from your body, which may affect how this medication works. Examples include azole antifungals (such as itraconazole), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Negative Interactions
2
- Esterified Estrogens
  Zinc
  Potential Negative Interaction
  This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.
  In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion. The clinical significance of this interaction remains unclear.
  Zinc
  Esterified Estrogens
  ×
  1. Herzberg M, Lusky A, Blonder J, Frenkel. The effect of estrogen replacement therapy on zinc in serum and urine. Obstet Gynecol 1996;87:1035-40.
- Methyltestosterone
  Zinc
  Potential Negative Interaction
  Taking methyltestosterone increased the amount of zinc in the blood and hair of boys with short stature or growth retardation. It is not known whether this increase would occur in other people or whether zinc supplementation by people taking methyltestosterone would result in zinc toxicity. Until more is known, zinc supplementation should be combined with methyltestosterone therapy only under the supervision of a doctor.
  Zinc
  Methyltestosterone
  ×
  1. Castro-Magana M, Collipp PJ, Chen SY et al. Zinc nutritional status, androgens, and growth retardation. Am J Dis Child 1981;135:322-5.
Explanation Required
2
- Methyltestosterone
  Androstenedione
  Needs Explanation
  This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.
  Andro supplementation has been shown to increase blood levels of testosterone in women, but not in men. No studies have investigated the possible additive effects of taking andro and methyltestosterone, but either increased drug effectiveness or more severe side effects are possible. Until more is known, these agents should be combined only under the supervision of a doctor.
  Androstenedione
  Methyltestosterone
  ×
  1. Mahesh VB, Greenblatt RB. The in vivo conversion of dehydroepiandrosterone and androstenedione to testosterone in the human. Acta Endocrinologica 1962;41:400-6.
  2. King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial. JAMA 1999;281:2020-8.
- Methyltestosterone
  DHEA
  Needs Explanation
  DHEA (Dehydroepiandrosterone) supplementation has been shown to increase blood levels of testosterone, as does methyltestosterone. No studies have investigated the possible additive effects of taking DHEA and methyltestosterone, but either increased drug effectiveness or more severe side effects are possible. Until more is known, these agents should be combined only under the supervision of a doctor.
  DHEA
  Methyltestosterone
  ×
  1. Wolf OT, Neumann O, Hellhammer DH, et al. Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men. J Clin Endocrinol Metab 1997;82:2263-7.
  2. Labrie F, Belanger A, Simard J, et al. DHEA and peripheral androgen and estrogen formation: Intracinology. Ann NY Acad Sci 1995;774:16-28.
  3. Morales AJ, Nolan JJ, Nelson JC, Yen SSC. Effects of replacement dose of DHEA in men and women of advancing age. J Clin Endorcrionol Metab 1994;78:1360.