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Drug

Gemfibrozil

Common brand names:

Lopid

Pronounced

"jem-FYE-broh-zill"

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: "blood thinners" (such as warfarin), colchicine, repaglinide, "statin" drugs (such as atorvastatin, lovastatin, simvastatin).

This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include daprodustat, elagolix, iptacopan, irinotecan, pioglitazone, resmetirom, selexipag, tovorafenib, among others.

Negative Interactions
1
- Gemfibrozil
  Red Yeast Rice
  Potential Negative Interaction
  Monascus purpureus, a form of red yeast, is fermented with rice to produce a dietary supplement, Cholestin®, that contains low levels of lovastatin, a drug otherwise available only by prescription. Gemfibrozil taken with the prescription drug lovastatin has been reported to cause rhabdomyolysis, a potentially life-threatening muscle disease. People taking gemfibrozil should avoid lovastatin-containing products, including Cholestin®, until more is known. The levels of lovastatin in Cholestin® are significantly lower than those given of the drug as a single agent. Cholestin® also contains numerous other compounds that may alter the interaction of lovastatin and gemfibrozil.
  Red Yeast Rice
  Gemfibrozil
  ×
  1. Garnett WR. Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors. Am J Health Syst Pharm 1995;52:1639-45.
Supportive Interactions
3
- Gemfibrozil
  Coenzyme Q10
  Replenish Depleted Nutrients
  In a randomized study of 21 men with combined hyperlipidemia, ten to twelve weeks of gemfibrozil therapy reduced coenzyme Q10 blood levels to the levels seen in healthy men. The clinical significance of this finding is unknown.
  Coenzyme Q10
  Gemfibrozil
  ×
  1. Aberg F, Appelkvist EL, Broijersen A, et al. Gemfibrozil-induced decrease in serum ubiquinone and alpha- and gamma-tocopherol levels in men with combined hyperlipidaemia. Eur J Clin Invest 1998;28:235-42.
- Gemfibrozil
  Vitamin E
  Replenish Depleted Nutrients
  In a randomized study of 21 men with combined hyperlipidemia, ten to twelve weeks of gemfibrozil therapy reduced alpha- and gamma-tocopherol blood levels to the levels seen in healthy men. The clinical significance of this finding is unknown and may reflect a normal physiological response to a reduction in serum cholesterol levels.
  Vitamin E
  Gemfibrozil
  ×
  1. Aberg F, Appelkvist EL, Broijersen A, et al. Gemfibrozil-induced decrease in serum ubiquinone and alpha- and gamma-tocopherol levels in men with combined hyperlipidaemia. Eur J Clin Invest 1998;28:235-42.
- Gemfibrozil
  Vitamin B3 (Niacin)
  Support Medicine
  Niacin (not niacinamide) and gemfibrozil have successfully raised HDL (good) cholesterol levels, both alone and in combination.
  Vitamin B3 (Niacin)
  Gemfibrozil
  ×
  1. Zema MJ. Gemfibrozil, nicotinic acid and combination therapy in patients with isolated hypoalphalipoproteinemia: a randomized, open-label, crossover study. J Am Coll Cardiol 2000;35:640-6.