Aisle7 Demo Web

Drug

Isosorbide Mononitrate

Common brand names:

ISMO

Pronounced

"eye-so-SORE-bide mow-no-NYE-trate"

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), riociguat, vericiguat.

Some products have ingredients that could worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

Isosorbide mononitrate is very similar to isosorbide dinitrate. Do not use medications containing isosorbide dinitrate while using isosorbide mononitrate.

This medication may interfere with certain lab tests (such as cholesterol levels), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Supportive Interactions
2
- Isosorbide Mononitrate
  N-Acetyl Cysteine
  Support Medicine
  In a double-blind trial, sustained-release ISMN plus oral NAC (2,400 mg twice per day) for two days led to significantly longer exercise time than ISMN plus placebo. This outcome suggests that NAC may have increased the efficacy of ISMN. There were no differences in side effects between the two groups.
  N-Acetyl Cysteine
  Isosorbide Mononitrate
  ×
  1. Svendsen JH, Klarlund K, Aldershvile J, Waldorff S. N-acetylcysteine modifies the acute effects of isosorbide-5-mononitrate in angina pectoris patients evaluated by exercise testing. J Cardiovasc Pharmacol 1989;13:320-3.
- Isosorbide Mononitrate
  Vitamin C
  Support Medicine
  This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.
  Some persons taking nitroglycerin or isosorbide mononitrate may find that it loses efficacy over time. This is because the body adapts to the drug, a process known as developing tolerance. One study found that taking 2 grams three times daily of vitamin C can decrease this effect when nitroglycerin patches are simultaneously used. Similar benefits have been confirmed in another study. However, it should be noted that it is also possible to avoid tolerance to these drugs by simply changing the dosing schedule. People taking ISMN or nitroglycerin should talk with their pharmacists about avoiding drug tolerance.
  Vitamin C
  Isosorbide Mononitrate
  ×
  1. Watanabe H, Kakihana M, Ohtsuka S, Sugishita Y. Randomized, double-blind, placebo-controlled study of the preventive effect of supplemental oral vitamin C on attenuation of development of nitrate tolerance. J Am Coll Cardiol 1998;31:1323-9.
  2. Bassenge E, Fink N, Skatchkov M, Fink B. Dietary supplement with vitamin C prevents nitrate tolerance. J Clin Invest 1998;102:67-71.