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Drug

Losartan

Common brand names:

Cozaar

Pronounced

"low-SAR-tan"

Drug Interactions

See also Precautions section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aliskiren, lithium, drugs that may increase the level of potassium in the blood (such as sparsentan, ACE inhibitors including benazepril/lisinopril, birth control pills containing drospirenone).

Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

Negative Interactions
2
- Losartan
  Potassium
  Potential Negative Interaction
  Losartan has caused significant increases in blood potassium levels. Potassium supplements, potassium-containing salt substitutes (No Salt, Morton Salt Substitute, and others), and even high-potassium foods (including Noni juice) should be avoided by those taking losartan, unless directed otherwise by their doctor.
  Potassium
  Losartan
  ×
  1. Noni. Natural Medicines Comprehensive Database [cited 2011 Sept 13]. Available from URL: www.naturaldatabase.com.
- Losartan
  Grapefruit
  Reduces Effectiveness
  Ingestion of grapefruit or grapefruit juice may increase the absorption of losartan by inhibiting an enzyme that breaks down the drug in the intestinal tract . Consumption of grapefruit products could therefore increase both the effectiveness and the adverse effects of this drug. People taking losartan should not use grapefruit products without medical supervision.
  Grapefruit
  Losartan
  ×
  1. Fuhr U. Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance. Drug Saf 1998;18:251-72.
Supportive Interactions
1
- Losartan
  Zinc
  Replenish Depleted Nutrients
  Losartan has been reported to increase urinary excretion of zinc, but the clinical significance of that finding is not certain.
  Zinc
  Losartan
  ×
  1. Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract 2013;67:717–25.