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Drug

Magnesium Hydroxide

Common brand names:

Milk Of Mag

Pronounced

"mag-NEE-zee-um hi-DROX-ide"

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: raltegravir, sodium polystyrene sulfonate.

Magnesium hydroxide can decrease the absorption of other drugs such as dasatinib, atazanavir, gabapentin, digoxin, mycophenolate, phosphate supplements (such as potassium phosphate), tetracycline antibiotics (such as doxycycline, minocycline), certain azole antifungals (ketoconazole, itraconazole), and quinolone antibiotics (such as ciprofloxacin, levofloxacin). Separate your doses of these medications as far as possible from your doses of magnesium hydroxide. Ask your doctor or pharmacist about how long you should wait between doses and for help finding a dosing schedule that will work with all your medications.

Supportive Interactions
2
- Magnesium Hydroxide
  Folic Acid
  Replenish Depleted Nutrients
  Folic acid is needed by the body to utilize vitamin B12. Antacids, including magnesium hydroxide, inhibit folic acid absorption. People taking antacids are advised to supplement with folic acid.
  Folic Acid
  Magnesium Hydroxide
  ×
  1. Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med 1988;112:458-63.
- Magnesium Hydroxide
  Iron
  Replenish Depleted Nutrients
  Antacids, including magnesium hydroxide, may reduce the absorption of dietary iron. Iron supplements do not require stomach acid for absorption and one human study found that a magnesium hydroxide/aluminum hydroxide antacid did not decrease supplemental iron absorption.
  Iron
  Magnesium Hydroxide
  ×
  1. O'Neil-Cutting MA, Crosby WH. The effect of antacids on the absorption of simultaneously ingested iron. JAMA 1986;255:1468-70.
Explanation Required
1
- Magnesium Hydroxide
  Potassium
  Needs Explanation
  Individuals taking potassium-depleting diuretics and those who are otherwise at risk of developing potassium deficiency (such as people with chronic diarrhea or vomiting) may experience a fall in serum potassium levels if they take magnesium without taking additional potassium. This could lead to muscle cramps or, in individuals taking digoxin or digitalis, more serious problems such as cardiac arrhythmias. Individuals who have a history of potassium deficiency and those who are at risk of developing potassium deficiency, as well as people taking digoxin or digitalis, should consult a physician before taking magnesium-containing products.
  Potassium
  Magnesium Hydroxide
  ×
  1. Dyckner T, Wester PO. Ventricular extrasystoles and intracellular electrolytes before and after potassium and magnesium infusions in patients on diuretic treatment. Am Heart J 1979;97:12-8.