Read the Patient Information Leaflet if available from your pharmacist before you start using mesalamine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Use this medication rectally as directed by your doctor, usually once daily at bedtime. The dosage is based on your medical condition and response to treatment.

Drink plenty of fluids during treatment with this medication unless otherwise directed by your doctor. This will help prevent kidney stones.

Before using, check this product for discoloration. The medication should be off-white to tan in color. A slight darkening of the medication is normal, but if the medication turns dark brown, do not use the enema.

This medication works best if you have a bowel movement before using it. Shake the bottle well. Holding the bottle at the neck, remove the cover from the applicator tip. Lie on your left side with your right knee bent. Insert the tip of the bottle into the rectum, pointing toward the navel. Gently and steadily squeeze out the entire contents of the bottle. Remove the bottle. Remain in position for 30 minutes. Throw away the empty bottle. Try to keep the medication in the rectum for 8 hours.

This medication may stain surfaces that it touches (such as clothing, floor, and counter surfaces).

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day.

Tell your doctor if your condition lasts or gets worse.