Read the Patient Information Leaflet if available from your pharmacist before you start using mesalamine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Use this medication rectally as directed by your doctor. If you are using the 1000-milligram strength product, it is usually used once daily at bedtime. If you are using a lower strength product, it is usually used 1 to 3 times daily. Follow your doctor's directions carefully. The dosage is based on your medical condition, response to treatment, and the strength of your prescription.

Drink plenty of fluids during treatment with this medication unless otherwise directed by your doctor. This will help prevent kidney stones.

This medication works best if you have a bowel movement before using it. Wash your hands before and after using the medication. Unwrap the suppository right before using. Try to handle it as little as possible because heat from your fingers may cause it to melt. Lie down on your left side with right knee bent. Gently insert the suppository, pointed end first, into the rectum with your finger. Use a small amount of lubricating gel on the tip of the suppository if desired. Remain lying down for a few minutes. Try to avoid having a bowel movement for 1 to 3 hours, keeping the suppository in place so the medicine can work.

This medication may stain surfaces that it touches (such as clothing, floor, and counter surfaces).

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Tell your doctor if your condition lasts or gets worse.