Drug
Nadolol
Pronounced
"nay-DOE-lole"
Drug Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: epinephrine, fingolimod.
Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).
Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).
Negative Interactions
5- Potential Negative Interaction
Nadolol
Pleurisy Root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as beta-blockers.
Pleurisy RootNadolol- Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213-4.
- Potential Negative Interaction
Nadolol
Potassium
People taking nadolol may experience significant increases in blood levels of potassium, though it is unknown whether supplementation with potassium might enhance this effect. People taking beta-blockers should therefore avoid taking potassium supplements, or eating large quantities of high-potassium foods, such as fruit (e.g., bananas), unless directed to do so by their doctor.
PotassiumNadolol- Wheeldon NM, McDevitt DG, Lipworth BJ. The effects of lower than conventional doses of oral nadolol on relative beta 1/beta 2-adrenoceptor blockade. Br J Clin Pharmacol 1994;38:103-8.
- Reduces Effectiveness
Nadolol
Calcium
Calcium supplements, if taken at the same time as some beta-blocker drugs, may reduce blood levels of the drug. However, whether calcium affects nadolol in this manner is unknown. Until more information is available, people on nadolol should take calcium supplements an hour before or two hours after the drug.
CalciumNadolol- Burnham TH, ed. Cardiovascular Agents, Antiadrenergics/Sympatholytics, Beta-Adrenergic Blocking Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, 2000, 467-79.
- Reduces Effectiveness
Nadolol
Green Tea
In a study of healthy volunteers, ingestion of green tea along with nadolol decreased the absorption of the drug and decreased its blood pressure-lowering effect. Based on this report, people taking nadolol should not consume green tea.Green TeaNadolol- Misaka S, Yatabe J, Muller F, et al. Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. Clin Pharmacol Ther 2014;95:432–8.
- Reduces Effectiveness
Nadolol
White Willow
The active compound in willow (Salix alba), salicin, is converted to salicylic acid in the body. Taking salicylates with other beta-adrenergic blocking drugs has resulted in decreased absorption of the drugs. Therefore, until more is known about the interaction between willow and nadolol, they should not be taken at the same time.
White WillowNadolol- Burnham TH, ed. Cardiovascular Agents, Antiadrenergics/Sympatholytics, Beta-Adrenergic Blocking Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, 2000, 467-79.