Aisle7 Demo Web

Drug

Nifedipine

Common brand names:

Adalat

Pronounced

"nye-FED-eh-peen"

Drug Interactions

See also the How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Other medications can affect the removal of nifedipine from your body, which may affect how nifedipine works. Examples include apalutamide, enzalutamide, mitotane, St. John's wort, rifamycins (such as rifabutin, rifampin), drugs used to treat seizures (such as carbamazepine, phenobarbital, phenytoin), among others.

Some products have ingredients that could raise your heart rate or worsen your chest pain. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

Explanation Required
3
- Nifedipine
  Grapefruit
  Needs Explanation
  Ingestion of grapefruit juice has been shown to increase the absorption of felodipine (a drug similar in structure and action to that of nifedipine) and to increase the adverse effects of the medication in patients with hypertension. People taking nifedipine or similar drugs should not consume grapefruit juice or grapefruit, unless they have discussed it with their physician.
  Grapefruit
  Nifedipine
  ×
  1. Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Br J Clin Pharmacol 1998;46:101-10.
- Nifedipine
  Pleurisy Root
  Needs Explanation
  As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as calcium channel blockers.
  Pleurisy Root
  Nifedipine
  ×
  1. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213-4.
- Nifedipine
  Pomegranate
  Needs Explanation
  Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice. The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with nifedipine in the same way that grapefruit juice does.
  Pomegranate
  Nifedipine
  ×
  1. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6.
  2. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472-3.