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Drug

Quinidine Gluconate

Common brand names:

Quinidex

Pronounced

"KWIN-ih-deen"

Drug Interactions

See also the How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: fingolimod, propafenone.

Other medications can affect the removal of quinidine from your body, which may affect how quinidine works. Examples include cobicistat, mifepristone, ritonavir, certain azole antifungals (including fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole), certain protease inhibitors (such as nelfinavir, tipranavir), among others.

This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include aliskiren, codeine, digoxin, mefloquine, tricyclic antidepressants (such as desipramine, imipramine), among others.

Many drugs besides quinidine may affect the heart rhythm (QT prolongation), including artemether/lumefantrine, ranolazine, toremifene, antiarrhythmic drugs (such as amiodarone, disopyramide, dofetilide, dronedarone, ibutilide, procainamide, sotalol), antipsychotics (such as pimozide, thioridazine, ziprasidone), certain quinolone antibiotics (grepafloxacin, sparfloxacin), among others.

Quinidine is very similar to quinine. Do not use medications containing quinine while using quinidine.

Negative Interactions
2
- Quinidine
  Grapefruit
  Potential Negative Interaction
  Drinking grapefruit juice together with quinidine increases the amount of time that the drug remains in the body, which might increase the likelihood of side effects and toxicity. Therefore, based on currently available information, people taking quinidine should avoid drinking grapefruit juice or eating grapefruit.
  Grapefruit
  Quinidine
  ×
  1. Damkier P, Hansen LL, Brosen K. Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine. Br J Clin Pharmacol 1999;48:829-38.
- Quinidine
  Pomegranate
  Potential Negative Interaction
  Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice. The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with quinidine in the same way that grapefruit juice does.
  Pomegranate
  Quinidine
  ×
  1. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6.
  2. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472-3.
Supportive Interactions
2
- Quinidine
  Beta-Carotene
  Reduce Side Effects
  Some people taking quinidine develop sensitivity to ultraviolet radiation from the sun. In a preliminary study, three people with quinidine-induced skin inflammation were able to tolerate intense sun exposure without recurrence of the rash after supplementing with 90–180 mg of beta-carotene each day. Further research is needed to confirm that people taking quinidine can prevent side effects by supplementing with beta-carotene.
  Beta-Carotene
  Quinidine
  ×
  1. Fisher DA. Quinidine photosensitivity. Arch Dermatol 1984;120:298 [letter].
- Quinidine
  Magnesium
  Reduce Side Effects
  This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.
  Two individuals taking sotalol developed a side effect of the drug (a heart arrhythmia known as torsades de pointes) which was effectively treated with intravenous magnesium. Additional research is needed to determine whether people taking sotalol might be able to prevent this side effect by taking supplemental magnesium.
  Magnesium
  Quinidine
  ×
  1. Sasse M, Paul T, Bergmann P, Kallfelz HC. Sotalol associated torsades de pointes tachycardia in a 15-month-old child: successful therapy with magnesium aspartate. Pacing Clin Electrophysiol 1998;21:1164-6.
  2. Arstall MA, Hii JT, Lehman RG, Horowitz JD. Sotalol-induced torsade de pointes: management with magnesium infusion. Postgrad Med J 1992;68:289-90.