Drug
Risedronate
Pronounced
"RIS-e-DROE-nate"
Drug Interactions
See also How to Use section.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Products that may interact with this drug include: medications that decrease stomach acid (such as antacids, H2 blockers including ranitidine, proton pump inhibitors including omeprazole).
This medication may interfere with certain lab tests (such as bone-imaging tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
Negative Interactions
2- Reduces Effectiveness
Risedronate
Iron
This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.
Taking risedronate at the same time as iron, zinc, or magnesium may reduce the amount of drug absorbed. Therefore, people taking risedronate who wish to supplement with these minerals should take them an hour before or two hours after the drug.
IronRisedronate- Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2504-6.
- Reduces Effectiveness
Risedronate
Zinc
This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.
Taking risedronate at the same time as iron, zinc, or magnesium may reduce the amount of drug absorbed. Therefore, people taking risedronate who wish to supplement with these minerals should take them an hour before or two hours after the drug.
ZincRisedronate- Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2504-6.
Explanation Required
3- Needs Explanation
Risedronate
Calcium
Short-term treatment with risedronate in people with hyperparathydoidism—a disorder characterized by high blood levels of calcium—resulted in lower calcium blood levels. Additional research is needed to determine whether people taking risedronate for Paget’s disease might develop low blood calcium levels. As a precaution, people with Paget’s disease should take supplemental calcium and vitamin D if dietary intake is inadequate. However, taking risedronate at the same time as calcium supplements reduces absorption of the drug. Therefore, people taking risedronate for Paget’s disease should take calcium supplements an hour before or two hours after taking the drug.
CalciumRisedronate- Reasner CA, Stone MD, Hosking DJ, et al. Acute changes in calcium homeostasis during treatment of primary hyperparathyroidism with risedronate. J Clin Endocrinol Metab 1993;77:1067-71.
- Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2504-6.
- Needs Explanation
Risedronate
Magnesium
Taking risedronate at the same time as iron, zinc, or magnesium may reduce the amount of drug absorbed. Therefore, people taking risedronate who wish to supplement with these minerals should take them an hour before or two hours after the drug.
MagnesiumRisedronate- Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2504-6.
- Needs Explanation
Risedronate
Vitamin D
Short-term treatment with risedronate in people with hyperparathydoidism—a disorder characterized by high blood levels of calcium—resulted in lower calcium blood levels. Additional research is needed to determine whether people taking risedronate for Paget’s disease might develop low blood calcium levels. As a precaution, people with Paget’s disease should take supplemental calcium and vitamin D if dietary intake is inadequate. However, taking risedronate at the same time as calcium supplements reduces absorption of the drug. Therefore, people taking risedronate for Paget’s disease should take calcium supplements an hour before or two hours after taking the drug.
Vitamin DRisedronate- Reasner CA, Stone MD, Hosking DJ, et al. Acute changes in calcium homeostasis during treatment of primary hyperparathyroidism with risedronate. J Clin Endocrinol Metab 1993;77:1067-71.
- Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2504-6.