Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking risedronate and each time you get a refill. Follow the instructions very closely to make sure you absorb as much of the drug as possible and reduce the risk of injury to your esophagus. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once per week. Choose the day of the week that best fits your schedule. Take this medication after getting up for the day, before taking your first food, beverage, or other medication. Do not take it at bedtime or while you are still in bed.

Take this medication with a full glass of plain water (6 to 8 ounces or 180 to 240 milliliters). Do not take it with any other beverages. Swallow the tablet whole. Do not chew or suck on it. Then stay fully upright (sitting, standing, or walking) for at least 30 minutes and do not lie down until after your first food of the day. Wait at least 30 minutes after taking risedronate before you eat or drink anything other than plain water and before taking any other medication by mouth.

Calcium or iron supplements, vitamins with minerals, antacids containing calcium/magnesium/aluminum, dairy products (such as milk, yogurt), and calcium-enriched juice may interfere with absorption of risedronate. Medications such as quinapril, sucralfate, and bismuth subsalicylate may also interfere with absorption. Do not take these products for at least 30 minutes after taking risedronate.

Take this medication regularly to get the most benefit from it. To help you remember, take it on the same day each week. Mark your calendar with a reminder. Talk to your doctor about the risks and benefits of long-term use of this medication.

Continue to take other medications for your condition as directed by your doctor.