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Drug

Sodium Bicarbonate

Pronounced

"SO-dee-um bye-KAR-buh-nate"

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug are: aspirin and other salicylates (such as salsalate), corticosteroids (such as prednisone), memantine, medications with a special coating to protect the stomach (enteric coating).

This medication can decrease the effectiveness of certain drugs that need stomach acid to work, including ampicillin, atazanavir, certain azole antifungals (such as ketoconazole, itraconazole), iron supplements, pazopanib, sucralfate, among others. Before using this medication, ask your doctor or pharmacist how to manage this possible interaction.

If your doctor has told you to take low-dose aspirin to prevent heart attack or stroke (usually 81-162 milligrams a day), you should keep taking the aspirin unless your doctor tells you not to. Ask your doctor or pharmacist for more details.

  • Supportive Interactions

    2

    • Sodium Bicarbonate

      Folic Acid

      Replenish Depleted Nutrients

      Folic acid is needed by the body to utilize vitamin B12. Antacids, including sodium bicarbonate, inhibit folic acid absorption. People taking antacids are advised to supplement with folic acid.

      Folic Acid
      Sodium Bicarbonate
      ×
      1. Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med 1988;112:458-63.

    • Sodium Bicarbonate

      Iron

      Replenish Depleted Nutrients

      In a study of nine healthy people, sodium bicarbonate administered with 10 mg of iron led to lower iron levels compared to iron administered alone. This interaction may be avoided by taking sodium bicarbonate-containing products two hours before or after iron-containing supplements.

      Iron
      Sodium Bicarbonate
      ×
      1. O'Neil-Cutting MA, Crosby WH. The effect of antacids on the absorption of simultaneously ingested iron. JAMA 1986;255:1468-70.

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Drug information is selected from data included with permission and copyrighted by First DataBank, Inc. This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional. Always seek the advice of your healthcare professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your healthcare professional. This information does not contain any assurances that this product is safe, effective or appropriate for you.

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Information expires December 2025.