Aisle7 Demo Web

Drug

Sodium Fluoride

Common brand names:

Bio Rince

Pronounced

"SO-dee-um FLOOR-ide"

Drug Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Supportive Interactions
3
- Sodium Fluoride
  Zinc
  Replenish Depleted Nutrients
  Individuals who are bedridden for long periods may become deficient in zinc, which can affect the strength of bone that is formed. In a controlled study of healthy adults who were confined to bed, fluoride supplementation prevented zinc loss from the body. Bedridden individuals should consult a qualified healthcare practitioner for guidance in using fluoride to prevent zinc deficiency.
  Zinc
  Sodium Fluoride
  ×
  1. Krebs JM, Schneider VS, LeBlanc AD. Zinc, copper and nitrogen balance during bed rest and fluoride supplementation in healthy adult males. Am J Clin Nutr 1998;47:509-14.
- Sodium Fluoride
  Vitamin D
  Support Medicine
  Collagen is a protein that is used in many areas of the body for structural support. One test tube study showed that the active form of vitamin D, 1,25 dihydroxycholecalciferol, increased the production of a certain type of collagen when it was combined with fluoride. Controlled research is needed to determine whether taking 1,25 dihydroxycholecalciferol with sodium fluoride might promote beneficial collagen growth.
  Vitamin D
  Sodium Fluoride
  ×
  1. Kassem M, Mosekilde L, Eriksen EF. 1,25-dihydroxy-vitamin D3 potentiates fluoride-stimulated collagen Type I production in cultures of human bone marrow stromal osteoblast-like cells. J Bone Miner Res 1993;8:1453-8.
- Sodium Fluoride
  Vitamin E
  Support Medicine
  Vitamin E increases the resistance of tooth enamel to acids that cause cavities, and test tube studies show that fluoride, when added to vitamin E, enhances this effect. Controlled research is needed to determine whether people might develop fewer cavities when taking vitamin E and fluoride together.
  Vitamin E
  Sodium Fluoride
  ×
  1. Yu H, Oho T, Xu LX. Effects of several tea components on acid resistance of human tooth enamel. J Dent 1995;23:101-5.
Explanation Required
1
- Sodium Fluoride
  Calcium
  Needs Explanation
  Research shows that calcium from leg bones may be transferred to bones in the spine causing stress fractures when fluoride is taken alone. However, supplementing with 1,500 mg of calcium each day together with slow-release forms of fluoride increases the bone density of the lumbar spine without causing fractures. Therefore, people taking sodium fluoride to treat osteoporosis should probably supplement with calcium to prevent this adverse effect. However, taking fluoride and calcium at the same time significantly reduces the absorption of fluoride; consequently, they should be taken at least an hour apart.
  Calcium
  Sodium Fluoride
  ×
  1. Deal CL. Osteoporosis: prevention, diagnosis, and management. Am J Med 1997;102:35s-9s.
  2. Ekstrand J, Spak CJ. Fluoride pharmacokinetics: its implication in the fluoride treatment of osteoporosis. J Bone Miner Res 1990;5 Suppl 1:s53-61.