Vitex is occasionally used as an herbal treatment for infertility—particularly in cases with established luteal phase defect (shortened second half of the menstrual cycle) and high levels of the hormone, prolactin. In one trial, 48 women (ages 23 to 39) who were diagnosed with infertility took vitex once daily for three months.¹ Seven women became pregnant during the trial, and 25 women experienced normalized progesterone levels—which may increase the chances for pregnancy. In another double-blind trial, significantly more infertile women became pregnant after taking a product whose main ingredient is vitex (the other ingredients were homeopathic preparations) than did those who took a placebo.² The amount used in this trial was 30 drops of fluid extract twice a day, for a total of 1.8 ml per day. This specific preparation is not available in the United States. Some doctors recommend taking 40 drops of a liquid extract of vitex each morning with water. Approximately 35–40 mg of encapsulated powdered vitex (one capsule taken in the morning) provides a similar amount. Vitex should be discontinued once a woman becomes pregnant.

A double-blind trial found that taking a multivitamin-mineral supplement increased female fertility.³

Some previously infertile women have become pregnant after supplementing with PABA (para-aminobenzoic acid), 100 mg four times per day.⁴ PABA is believed to increase the ability of estrogen to facilitate fertility.

Vitamin E deficiency in animals leads to infertility.⁵ In a preliminary human trial, infertile couples given vitamin E (200 IU per day for the female and 100 IU per day for the male) showed a significant increase in fertility.⁶