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Nutritional Supplement

Astaxanthin

  • Digestive Support

    Indigestion, Heartburn, and Low Stomach Acidity

    The carotenoid astaxanthin may inhibit the growth of Helicobacter pylori and reduce related gastric inflammation.
    Indigestion, Heartburn, and Low Stomach Acidity
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    Astaxanthin is a member of the carotenoid family that has an inhibitory effect on the growth of Helicobacter pylori,3 and reduces gastric inflammation related to this organism, according to animal studies.4,5 In a double-blind trial of people with functional dyspepsia, those who were infected with H. pylori had reduced symptoms of acid reflux when they took 40 mg per day of astaxanthin, but a lower amount of 16 mg per day was not helpful, and neither amount of astaxanthin improved other symptoms of dyspepsia. In subjects who were not infected with Helicobacter pylori, neither amount of astaxanthin was effective.6

    Gastritis

    The carotenoid astaxanthin may inhibit the growth of Helicobacter pylori and reduce related gastric inflammation.
    Gastritis
    ×
    Astaxanthin is a member of the carotenoid family that has an inhibitory effect on the growth of Helicobacter pylori,7 and reduces gastric inflammation related to this organism, according to animal studies.8,9 In a double-blind trial of people with functional dyspepsia, those who were infected with H. pylori had reduced symptoms of acid reflux when they took 40 mg per day of astaxanthin, but a lower amount of 16 mg per day was not helpful, and neither amount of astaxanthin improved other symptoms of dyspepsia. In subjects who were not infected with Helicobacter pylori, neither amount of astaxanthin was effective.10
  • Heart and Circulatory Health

    High Triglycerides

    Astaxanthin has antioxidant and other properties that might support proper regulation of blood lipids.
    High Triglycerides
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    Astaxanthin is a member of the carotenoid family that has antioxidant and other properties that might support proper regulation of blood lipids.11,12 One double-blind trial in normal weight people with high blood triglycerides found astaxanthin, taken in amounts of either 12 mg or 18 mg per day, lowered blood triglycerides.13 However, in another double-blind trial in overweight people with normal triglycerides, 20 mg per day of astaxanthin had no significant effect on blood triglycerides.14

    High Cholesterol

    Astaxanthin has antioxidant and other properties that may help improve cholesterol metabolism and protect vascular health.
    High Cholesterol
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    Astaxanthin is a red carotenoid pigment found in microalgae as well as some seafood such as salmon, shrimp, and trout.15 Astaxanthin is an antioxidant and has demonstrated an ability to improve cholesterol metabolism and protect vascular health.16,17,15 One randomized controlled trial in 61 people with high blood triglycerides found 6 mg and 12 mg of astaxanthin daily for 12 weeks increased HDL-cholesterol levels, but 18 mg per day did not.19 In another placebo-controlled trial that included 27 overweight participants, LDL-cholesterol levels decreased in those who received 20 mg of astaxanthin per day for 12 weeks, while no change was seen in those who received placebo, although the difference between the two groups was not statistically significant (possibly due to the small size of the trial).20 However, a meta-analysis that pooled findings from seven randomized controlled trials found astaxanthin had no beneficial effect on lipid profiles.21
  • Fitness

    Athletic Performance

    Astaxanthin is a member of the carotenoid family with strong antioxidant properties that might protect against the oxidative stress of exercise.
    Athletic Performance
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    Astaxanthin is a member of the carotenoid family with strong antioxidant properties that might protect against the oxidative stress of exercise.21 Animal studies also suggest a potential effect of astaxanthin on energy metabolism.22,23 In a double-blind trial, elite soccer players who took 4 mg per day of astaxanthin for three months had lower blood measures of muscle damage and oxidative stress after a two-hour training session.24 However, in another double-blind trial in weight-training men, 4 mg astaxanthin per day for three weeks did not reduce either muscle soreness, muscle weakness, or blood measures of muscle damage following a bout of intense weight-lifting.25 A double-blind trial of endurance athletes found that 4 mg per day astaxanthin for four weeks shortened the time required to complete a distance cycling trial.26 However, in another double-blind trial, endurance performance was not improved by taking 20 mg astaxanthin per day for four weeks.27
  • Men's Health

    Male Infertility

    Male Infertility
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    Astaxanthin is a member of the carotenoid family that has antioxidant and other properties that might support normal sperm function.28 In a double-blind trial,[REF] infertile men were given 16 mg per day of astaxanthin for three months. While measures of sperm function did not significantly improve, more pregnancies occurred in the group taking astaxanthin compared to the placebo group.
  • Healthy Aging/Senior Health

    Anti-Aging

    Astaxanthin might support skin health by reducing fine lines and wrinkles and improving skin elasticity.
    Anti-Aging
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    Astaxanthin is a member of the carotenoid family that has antioxidant and other properties that might support skin health.29,30 In a controlled trial in women, 4 mg astaxanthin per day reduced fine lines and wrinkles and improved skin elasticity, but did not significantly affect skin moisture.31 In a double-blind trial in men, 6 mg astaxanthin per day improved skin elasticity, as well as two out of six measures of wrinkle severity and one out of three measures of skin moisture, but did not affect skin oil production.30

    Age-Related Cognitive Decline

    Some, though not all, research has found astaxanthin might protect the brain from age-related oxidative damage.
    Age-Related Cognitive Decline
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    Astaxanthin is a member of the carotenoid family with strong antioxidant properties that might protect the brain from age-related oxidative damage.32 In a preliminary study, 12 mg per day of astaxanthin given to people with complaints of age-related forgetfulness for twelve weeks improved some measures of brain function,33 but a double-blind trial using similar amounts found no significant effects of astaxanthin on cognitive impairment compared to a placebo.34
  • Brain Health

    Age-Related Cognitive Decline

    Some, though not all, research has found astaxanthin might protect the brain from age-related oxidative damage.
    Age-Related Cognitive Decline
    ×
    Astaxanthin is a member of the carotenoid family with strong antioxidant properties that might protect the brain from age-related oxidative damage.35 In a preliminary study, 12 mg per day of astaxanthin given to people with complaints of age-related forgetfulness for twelve weeks improved some measures of brain function,36 but a double-blind trial using similar amounts found no significant effects of astaxanthin on cognitive impairment compared to a placebo.37
What Are Star Ratings?
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Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

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References

1. Higuera-Ciapara I, Félix-Valenzuela L, Goycoolea FM. Astaxanthin: a review of its chemistry and applications. Crit Rev Food Sci Nutr 2006;46:185-96 [review].

2. Guerin M, Huntley ME, Olaizola M. Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol 2003;21:210-6 [review].

3. Akyön Y. Effect of antioxidants on the immune response of Helicobacter pylori. Clin Microbiol Infect 2002;8:438-41.

4. Wang X, Willén R, Wadström T. Astaxanthin-rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice. Antimicrob Agents Chemother 2000;44:2452-7.

5. Bennedsen M, Wang X, Willén R, et al. Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes. Immunol Lett 1999;70:185-9.

6. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: a prospective, randomized, double blind, and placebo controlled study. Phytomedicine 2008;15:391-9.

7. Akyön Y. Effect of antioxidants on the immune response of Helicobacter pylori. Clin Microbiol Infect 2002;8:438-41.

8. Wang X, Willén R, Wadström T. Astaxanthin-rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice. Antimicrob Agents Chemother 2000;44:2452-7.

9. Bennedsen M, Wang X, Willén R, et al. Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes. Immunol Lett 1999;70:185-9.

10. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: a prospective, randomized, double blind, and placebo controlled study. Phytomedicine 2008;15:391-9.

11. Hussein G, Nakagawa T, Goto H, et al. Astaxanthin ameliorates features of metabolic syndrome in SHR/NDmcr-cp. Life Sci 2007; 80:522-9.

12. Fassett RG, Coombes JS. Astaxanthin in cardiovascular health and disease. Molecules 2012 20;17:2030-48 [review].

13. Yoshida H, Yanai H, Ito K, et al. Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis. 2010;209:520–3.

14. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr 2011;66:363–9.

15. Kishimoto Y, Yoshida H, Kondo K. Potential Anti-Atherosclerotic Properties of Astaxanthin. Mar Drugs 2016;14:35.

16. Fanaee-Danesh E, Gali CC, Tadic J, et al. Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells. Biochim Biophys Acta Mol Basis Dis 2019;1865:2224–45.

17. Zou TB, Zhu SS, Luo F, et al. Effects of Astaxanthin on Reverse Cholesterol Transport and Atherosclerosis in Mice. Biomed Res Int 2017;2017:4625932.

18. Yoshida H, Yanai H, Ito K, et al. Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis. 2010;209:520–3.

19. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr 2011;66:363–9.

20. Ursoniu S, Sahebkar A, Serban MC, et al. Lipid profile and glucose changes after supplementation with astaxanthin: a systematic review and meta-analysis of randomized controlled trials. Arch Med Sci 2015;11:253–66.

21. Aoi W, Naito Y, Sakuma K, et al. Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal 2003;5:139-44.

22. Aoi W, Naito Y, Takanami Y, et al. Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. Biochem Biophys Res Commun 2008 22;366:892-7.

23. Ikeuchi M, Koyama T, Takahashi J, Yazawa K. Effects of astaxanthin supplementation on exercise-induced fatigue in mice. Biol Pharm Bull 2006;29:2106-10.

24. Djordjevic B, Baralic I, Kotur-Stevuljevic J, et al. Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. J Sports Med Phys Fitness 2012;52:382-92.

25. Bloomer RJ, Fry A, Schilling B, et al. Astaxanthin supplementation does not attenuate muscle injury following eccentric exercise in resistance-trained men. Int J Sport Nutr Exerc Metab 2005;15:401-12.

26. Earnest CP, Lupo M, White KM, Church TS. Effect of astaxanthin on cycling time trial performance. Int J Sports Med 2011;32:882-8.

27. Res PT, Cermak NM, Stinkens R, et al. Astaxanthin supplementation does not augment fat use or improve endurance performance. Med Sci Sports Exerc 2013;45:1158-65.

28. Comhaire FH, Mahmoud A. The role of food supplements in the treatment of the infertile man. Reprod Biomed Online 2003;7:385-91 [review].

29. Yuan JP, Peng J, Yin K, Wang JH. Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Mol Nutr Food Res 2011;55:150-65 [review].

30. Tominaga K, Hongo N, Karato M, Yamashita E. Cosmetic benefits of astaxanthin on humans subjects. Acta Biochim Pol 2012;59:43-7.

31. Yamashita E. The effect of a dietary supplement containing astaxanthin on skin condition. Carotenoid Sci 2006;10:91-5.

32. Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev 2011;16:355-64 [review].

33. Satoh A, Tsuji S, Okada Y, et al. Preliminary clinical evaluation of toxicity and efficacy of a new astaxanthin-rich Haematococcus pluvialis extract. J Clin Biochem Nutr 2009;44:280–4.

34. Katagiri M, Satoh A, Tsuji S, Shirasawa T. Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study. J Clin Biochem Nutr 2012;51:102-7.

35. Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev 2011;16:355-64 [review].

36. Satoh A, Tsuji S, Okada Y, et al. Preliminary clinical evaluation of toxicity and efficacy of a new astaxanthin-rich Haematococcus pluvialis extract. J Clin Biochem Nutr 2009;44:280–4.

37. Katagiri M, Satoh A, Tsuji S, Shirasawa T. Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study. J Clin Biochem Nutr 2012;51:102-7.

38. Higuera-Ciapara I, Félix-Valenzuela L, Goycoolea FM. Astaxanthin: a review of its chemistry and applications. Crit Rev Food Sci Nutr 2006;46:185-96 [review].

39. Guerin M, Huntley ME, Olaizola M. Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol 2003;21:210-6 [review].

40. Electronic Code of Federal Regulations, Title 21, Subpart A, § 73.35. Astaxanthin [cited 2013 Aug 17]. Available from URL: www.ecfr.gov.

41. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J 2008;22:659-61 [review].

42. Stewart JS, Lignell A, Pettersson A, et al. Safety assessment of astaxanthin-rich microalgae biomass: Acute and subchronic toxicity studies in rats. Food Chem Toxicol 2008;46:3030-6.

43. Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev 2011;16:355-64 [review].

44. Satoh A, Tsuji S, Okada Y, et al. Preliminary clinical evaluation of toxicity and efficacy of a new astaxanthin-rich Haematococcus pluvialis extract. J Clin Biochem Nutr 2009;44:280–4.

45. Spiller GA, Dewell A. Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial. J Med Food 2003;6:51-6.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.