Boldo contains several types of primary constituents, including volatile oils (for example, ascaridole, eucalyptol), flavonoids, and alkaloids. Boldine, which constitutes about one-fourth of the total number of alkaloids present, is the major alkaloid.² Scientists believe that boldine is responsible for the plant’s choloretic (bile stimulating) and diuretic actions.² In conjunction with other herbs, such as cascara, rhubarb, and gentian, boldo has been reported to improve appetite.⁴ Ascaridole, a compound found in the volatile oil of the plant, has been used as an anti-parasitic agent but is no longer recommended due its to toxic side effects.⁴