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Nutritional Supplement

Egg Protein

Egg protein is derived primarily from egg whites and is a complete protein, providing adequate proportions of all of the body’s required (essential) amino acids.1 It is highly ranked for protein quality and digestibility,2 and is relatively high in branched-chain amino acids, which are used primarily to make and repair muscle tissue. Egg protein is sometimes used in protein supplements and protein-enriched foods.

Egg protein contains a compound called avidin, which is well known to interfere with the absorption of biotin, a B-complex vitamin.3 Ordinarily, people who eat eggs are not exposed to enough avidin to have a significant impact, and avidin is also neutralized with heat. However, those who eat raw egg whites on a daily basis or people using large amounts of egg protein supplements might need to be concerned. Because of this issue, some egg protein supplements are heated during processing and are promoted as “avidin-neutralized.”

References

1. Lemon P. Beyond the zone: protein needs of active individuals. J Am Coll Nutr 2000;19:513S-521S.

2. Hernandez M, Montalvo I, Sousa V, Sotelo A. The protein efficiency ratios of 30:70 mixtures of animal:vegetable protein are similar or higher than those of the animal foods alone. J Nutr 1996;126:574-81.

3. Rodriguez Melendez R. Importance of biotin metabolism. Rev Invest Clin 2000;52:194-9. [in Spanish]

4. Sundell J, Hulmi J, Rossi J. Whey protein and creatine as nutritional supplements. Duodecim 2011;127:700-5. [in Finnish]

5. Paul G. The rationale for consuming protein blends in sports nutrition. J Am Coll Nutr 2009;28 Suppl:464S-472S.

6. Moore D, Robinson M, Fry J, et al. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr 2009;89:161-8. doi: 10.3945/ajcn.2008.26401.

7. Hida A, Hasegawa Y, Mekata Y, et al. Effects of egg white protein supplementation on muscle strength and serum free amino acid concentrations. Nutrients 2012;4:1504-17. doi: 10.3390/nu4101504.

8. Mekata Y, Hayashi N, Masuda Y, et al. Blood substrates and hormonal responses to increased egg white protein intake prior to a 12,000 m run in heat. J Nutr Sci Vitaminol (Tokyo) 2008;54:154-62.

9. Zhang B, Liu J, Liu C, et al. Bifunctional peptides with antioxidant and angiotensin-converting enzyme inhibitory activity in vitro from egg white hydrolysates. J Food Biochem 2020 09;44:e13347.

10. Lee DE, Jung TH, Jo YN, et al. Enzymatic Hydrolysis of Egg White Protein Exerts a Hypotensive Effect in Spontaneously Hypertensive Rats. Food Sci Anim Resour 2019;39:980–7.

11. Plat J,Severins N, Morrison S, et al. Effects of NWT-03, an egg-protein hydrolysate, on blood pressure in normotensive, high-normotensive and mild-hypertensive men and women: a dose-finding study. Br J Nutr 2017;117:942–50.

12. Lucey AJ, Heneghan C, Manning E, et al. Effect of an egg ovalbumin-derived protein hydrolysate on blood pressure and cardiovascular risk in adults with a mildly elevated blood pressure: a randomized placebo-controlled crossover trial. Eur J Nutr 2019;58:2823–33.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.