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Nutritional Supplement

Grapefruit Seed Extract

  • Negative Interactions

    1

    • Grapefruit Seed Extract

      Warfarin

      Potential Negative Interaction

      In case reports, ingestion of grapefruit seed extract interfered with the effect of warfarin. This inhibitory effect appeared to be due to benzethonium chloride, a synthetic preservative that is added to most grapefruit seed extract products.

      Warfarin
      Grapefruit Seed Extract
      ×
      1. Brandin H, Myrberg O, Rundlof T, et al. Adverse effects by artificial grapefruit seed extract products in patients on warfarin therapy. Eur J Clin Pharmacol 2007;63:565-70.

References

1. Ionescu G, Kiehl R, Wichmann-Kunz F, et al. Oral citrus seed extract in atopic eczema: In vitro and in vivo studies on intestinal microflora. J Orthomol Med 1990;5:155-8.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.