Caution: Based on several reports of liver toxicity from greater celandine, it connot be recommended as a treatment for indigestion.¹⁴

Bitter herbs are thought to stimulate digestive function by increasing saliva production and promoting both stomach acid and digestive enzyme production.¹⁵ As a result, they are particularly used when there is low stomach acid but not in heartburn (where too much stomach acid could initially exacerbate the situation). These herbs literally taste bitter. Some examples of bitter herbs include greater celandine, wormwood, gentian,dandelion, blessed thistle, yarrow, devil’s claw, bitter orange, bitter melon, juniper, andrographis, prickly ash, and centaury.¹⁶ Bitters are generally taken either by mixing 1–3 ml tincture into water and sipping slowly 10–30 minutes before eating, or by making tea, which is also sipped slowly before eating.

A double-blind study found that a standardized extract of greater celandine could relieve symptoms of indigestion (such as abdominal cramping, sensation of fullness, and nausea) significantly better than placebo.¹⁷ The study employed an extract standardized to 4 mg of chelidonine per capsule and gave 1–2 tablets three times daily for six weeks. However, recent reports of hepatitis following intake of greater celandine have raised concerns about its safety for treating indigestion.¹⁸

Herbalists have sometimes recommended the use of greater celandine (Chelidonium majus) for the topical treatment of warts.¹⁹ The milky juice from the fresh plant is typically applied to the wart once daily and allowed to dry.