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Nutritional Supplement

PABA

Also indexed as:Para-Aminobenzoic Acid

  • Negative Interactions

    4

    • PABA

      Methotrexate

      Potential Negative Interaction

      PABA can increase methotrexate levels, activity, and side effects. The incidence and severity of this interaction remains unclear.

      Methotrexate
      PABA
      ×
      1. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 170.

    • PABA

      Sulfamethoxazole

      Potential Negative Interaction

      PABA may interfere with the activity of sulfamethoxazole. PABA should not be taken with this drug until more is known.

    • PABA

      Sulfasalazine

      Potential Negative Interaction

      PABA may interfere with the activity of sulfasalazine. PABA should not be taken with this drug until more is known.

    • PABA

      Trimethoprim/ Sulfamethoxazole

      Potential Negative Interaction

      PABA (para-aminobenzoic acid) may interfere with the action of sulfamethoxazole. It should not be taken together with trimethoprim/sulfamethoxazole.

  • Supportive Interactions

    1

    • PABA

      Dapsone

      Replenish Depleted Nutrients

      PABA (para-aminobenzoic acid) is a compound found in foods that is considered by some to be a member of the B-vitamin family. PABA may interfere with the activity of dapsone. Read supplement product labels for PABA content.

      Dapsone
      PABA
      ×
      1. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 88.

References

1. Sieve BF. The clinical effects of a new B-complex factor, para-aminobenzoic acid, on pigmentation and fertility. South Med Surg 1942;104:135-9.

2. Zarafonetis CJ, Johnwick EB, Kirkman LW, Curtis AC. Paraaminobenzoic acid in dermatitis herpetiformis. Arch Dermatol Syph 1951;63:115-32.

3. Sieve BF. Further investigations in the treatment of vitiligo. Virginia Med Monthly 1945;Jan:6-17.

4. Kantor GR, Ratz JL. Liver toxicity from potassium para-aminobenzoate. J Am Acad Dermatol 1985;13:671-2.

5. Hughes CG. Oral PABA and vitiligo. J Am Acad Dermatol 1983;9:770 [letter].

6. Worobec S, LaChine A. Dangers of orally administered para-aminobenzoic acid. JAMA 1984;251:2348.

7. Zarafonetis CJD, Grekin RH, Curtis AC, et al. Further studies on the treatment of lupus erythematosus with sodium para-aminobenzoate. J Invest Dermatol 1948;11:359.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.