No serious side effects have been reported with 300–400 mg per day. Larger amounts (such as 8 grams per day or more) may cause low blood sugar, rash, fever, and (on rare occasions) liver damage.⁴ One report exists of vitiligo appearing after ingestion of large amounts of PABA⁵ and use of amounts over 20 grams per day in small children has resulted in deaths.⁶ There is also a report of a death from toxic hepatitis in a person with lupus, who took as much as 48 grams per day for six days, followed by 8 grams per day for seven months.⁷