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Patient Education Monograph

Glyburide Oral

Common brand names:

Diabeta, Euglucon

Pronounced

"GLY-byur-ide"

Drug Interactions

See also How To Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

A product that may interact with this drug is: bosentan.

Many drugs can affect your blood sugar, making it harder to control. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Beta-blocker medications (including metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs.

  • Negative Interactions

    1

    • Glyburide

      Ginkgo

      Potential Negative Interaction

      In a preliminary trial, administration of Ginkgo biloba extract (120 mg per day) for three months to patients with type 2 diabetes who were taking oral anti-diabetes medication resulted in a significant worsening of glucose tolerance. Ginkgo did not impair glucose tolerance in individuals whose diabetes was controlled by diet. Individuals taking oral anti-diabetes medication should consult a doctor before taking Ginkgo biloba.

      Ginkgo
      Glyburide
      ×
      1. Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract (EGb 761) on pancreatic beta-cell function in response to glucose loading in individuals with non-insulin-dependent diabetes mellitus. J Clin Pharmacol 2001;41:600-11.

  • Supportive Interactions

    1

    • Glyburide

      Aloe

      Support Medicine

      One single-blind study in Thailand reported that combining 1 Tbsp (15 ml) of aloe (Aloe vera) juice twice daily with glyburide significantly improved blood sugar and lipid levels in people with diabetes, compared with placebo. Previously, glyburide by itself had not effectively controlled the diabetes in the people in this study.

      Aloe
      Glyburide
      ×
      1. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine 1996;3:245-8.

  • Explanation Required

    3

    • Glyburide

      Biotin

      Needs Explanation

    • Glyburide

      Chromium

      Needs Explanation

      Chromium supplements have been shown to improve blood sugar control in people with diabetes. Consequently, supplementing with chromium could reduce blood sugar levels in people with taking glyburide, potentially resulting in abnormally low blood sugar levels (hypoglycemia). While chromium supplementation may be beneficial for people with diabetes, its use in combination with glyburide or with any other blood sugar-lowering medication should be supervised by a doctor.

      Chromium
      Glyburide
      ×
      1. Anderson RA, Cheng N, Bryden NA, Polansky MM, Cheng N, Chi J, et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes1997;46:1786-91.

    • Glyburide

      Gymnema

      Needs Explanation

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Drug information is selected from data included with permission and copyrighted by First DataBank, Inc. This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional. Always seek the advice of your healthcare professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your healthcare professional. This information does not contain any assurances that this product is safe, effective or appropriate for you.

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Information expires December 2025.