Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: corticosteroids (such as prednisone), mavacamten, methotrexate (especially high-dose treatment), mifepristone, ginkgo biloba, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, ticagrelor, NSAIDs such as ibuprofen/naproxen, "blood thinners" such as warfarin/dabigatran).

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as ibuprofen or naproxen). These drugs are similar to this medication and may increase your risk of side effects if taken together. Ask your doctor or pharmacist for more details.

Some products need stomach acid so that the body can absorb them properly. Omeprazole decreases stomach acid, so it may change how well these products work. Some affected products include atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, sparsentan, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others.

Other medications can affect the removal of omeprazole from your body, which may affect how this product works. Examples include rifampin, St John's wort, among others.

Omeprazole is very similar to esomeprazole. Do not use any medications containing esomeprazole while using omeprazole.

This medication may interfere with certain lab or medical tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.