Before taking this medication, tell your doctor or pharmacist if you are allergic to conjugated estrogens or bazedoxifene; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: vaginal bleeding of unknown cause, diabetes, cancer (especially breast cancer, cancer of the uterus/ovaries), blood clots, blood clotting disorders (such as protein C or protein S deficiency), family medical history (especially of breast lumps, cancer, blood clots), family or personal history of a certain swelling disorder (angioedema), gallbladder disease, heart disease (such as irregular heartbeat, previous heart attack), high blood pressure, high cholesterol/triglyceride levels, kidney disease, liver disease, lupus, mental/mood disorders (such as dementia, depression), migraine headaches, underactive thyroid (hypothyroidism), mineral imbalance (low or high level of calcium in the blood), obesity, a certain hormone problem (hypoparathyroidism), uterus problems (such as fibroids, endometriosis), asthma, seizures, stroke, a certain blood disorder (porphyria).

Do not smoke or use tobacco. Estrogens combined with smoking further increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35.

Tell your doctor if you just had or will be having surgery, or if you will be confined to a chair or bed for a long time (such as a long plane flight). These conditions increase your risk of getting blood clots, especially if you are taking an estrogen product. You may need to stop this medication for a time or take special precautions.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may cause blotchy, dark areas on your face and skin (melasma). Sunlight may worsen this effect. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.

If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses. Contact your eye doctor if these problems occur.

This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor right away.

Estrogens pass into breast milk and may reduce the quality and amount of breast milk produced. It is unknown if bazedoxifene passes into breast milk. Breastfeeding is not recommended while using this medication. Consult your doctor before breastfeeding.