Read the Patient Information Leaflet if available from your pharmacist before you start using crizanlizumab and each time you get an infusion. If you have any questions, ask your doctor or pharmacist.

This medication is given by a health care professional. It is given as directed by your doctor on a treatment schedule. It is injected slowly into a vein usually over 30 minutes. The first 2 infusions are usually given 2 weeks apart. After that, an infusion is usually given every 4 weeks. Follow your doctor's treatment schedule.

Infusion reactions may happen during the infusion of this drug and for up to 24 hours afterward. Your doctor may prescribe other medications (such as acetaminophen, nonsteroidal anti-inflammatory drugs-NSAIDs, antihistamines) before each treatment to help prevent these side effects. Tell your doctor right away if you have symptoms of infusion reactions such as pain, headache, dizziness, fever, chills, shivering, nausea, vomiting, diarrhea, itching, or trouble breathing. Your doctor may slow down or stop your treatment for some time.

The dosage and treatment schedule are based on your medical condition, weight, and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, mark the days on the calendar when you need to receive the medication.