Take this medication by mouth exactly as directed by your doctor. The dosage is based on your medical condition, weight, response to treatment, and other treatments (such as other chemotherapy drugs, radiation) you may be receiving. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During treatment with this medication, you must drink more fluids than usual and pass urine often to help avoid kidney and bladder side effects. Ask your doctor how much you should drink and how often to empty your bladder each day, and follow these instructions carefully.

Swallow the tablets/capsules whole. Do not chew or crush the tablets/capsules. Do not open the capsules. If you have accidental contact with broken tablets/capsules, wash your hands thoroughly right away.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe dust from the tablets or capsules.

Do not increase your dose or take this medication more often without your doctor's approval. Your condition will not improve any faster and the risk of serious side effects may be increased.