Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

A product that may interact with this drug is: digoxin.

Many drugs besides erythromycin may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, propafenone, quinidine, sotalol, among others.

Other medications can affect the removal of erythromycin from your body, which may affect how erythromycin works. Examples include azole antifungals (such as itraconazole, ketoconazole), certain calcium channel blockers (such as diltiazem, verapamil), quinupristin-dalfopristin, certain drugs for seizures (such as carbamazepine, phenytoin, valproate), among others.

This medication can slow down the removal of other medications from your body, which may affect how they work. Examples include bromocriptine, certain benzodiazepines (alprazolam, midazolam, triazolam), colchicine, eletriptan, certain drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), ergot alkaloids (such as ergotamine, dihydroergotamine), certain "statin" drugs (such as lovastatin, simvastatin), vinblastine, among others.

This medication may interfere with certain lab tests (such as urine tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.