See also Warning section.

Read the Medication Guide provided by your pharmacist before you start using esketamine and each time you go for treatment. If you have any questions, ask your doctor or pharmacist.

To reduce the risk of nausea and vomiting, avoid food for at least 2 hours before treatment, and avoid drinking liquids for at least 30 minutes before treatment.

If you have a stuffy nose, ask your doctor if you should use a corticosteroid spray or decongestant drops/spray in your nose at least 1 hour before esketamine treatment.

A health care professional will give you instructions for how to use the nasal spray device. Blow your nose before you start treatment. You may need to use more than one spray device based on your dose. Spray once in each nostril per device. Lean your head back and rest for 5 minutes after using each device. Do not blow your nose right after a dose.

You will be monitored during each treatment and afterward for at least 2 hours. You will need to have someone drive you home after each treatment.

The dosage and treatment schedule are based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, mark your calendar with the treatment dates.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as cravings, tiredness, poor appetite, anxiety). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used esketamine for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Tell your doctor if your condition does not get better or if it gets worse.