Take this medication by mouth on an empty stomach (1 hour before or 2 hours after a meal) as directed by your doctor, usually 3 to 4 times a day.

Take this medication with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same times each day as directed. The dosage is based on your medical condition, weight, and response to treatment.

Take this medication 3 hours before or after taking any products containing magnesium, aluminum, or calcium. Some examples include quinapril, vitamins/minerals, and antacids. Dairy products (such as milk, yogurt), calcium-enriched juice, sucralfate, bismuth subsalicylate, iron, and zinc are also included. These products bind with estramustine, preventing its full absorption.

Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.

Since this drug can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules.