Read the Patient Information Leaflet if available from your pharmacist before you start taking glyburide and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Glyburide comes in different types of tablets which provide different amounts of the medication. Do not switch between different forms or brands of this medication unless directed by your doctor.

Take this medication by mouth with breakfast or the first main meal of the day as directed by your doctor, usually once daily. Some patients, especially those taking higher doses, may be directed to take this drug twice a day. The dosage is based on your medical condition and response to treatment.

To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

If you are already taking another diabetes drug (such as chlorpropamide), follow your doctor's directions carefully for stopping the old drug and starting glyburide.

If you are also taking colesevelam, take glyburide at least 4 hours before colesevelam.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Tell your doctor if your condition does not improve or if it worsens (your blood sugar is too high or too low).