Read the Patient Information Leaflet if available from your pharmacist before you start taking midostaurin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with food as directed by your doctor, usually twice daily (every 12 hours). Swallow the capsules whole. Do not open or crush the capsules.

The dosage is based on your medical condition and response to treatment. For certain conditions, you may not need to take this medication every day (for example, some people are directed to take the medication for 2 weeks, then stop for 2 weeks). Follow your doctor's instructions carefully.

Your doctor should instruct you to take other medications to prevent nausea and vomiting. Take those medications as directed.

If you vomit after taking a dose, do not take another dose at that time. Take your next dose on your usual dosing schedule.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.